TPDB

3D PDB MODEL

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TPDB ID TPDB47316

Peptide_Name

ACE Inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

YYAPFE

FASTA

>TPDB47316|ACE inhibitors;Antihypertensive|length=6
YYAPFE

Formula C40H48N6O11

Absent Amino Acids RNDCQGHILKMSTWV

Common Amino Acids Y

Mass 788.85

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -1

Boman Index -0.71

Hydrophobicity -0.517

Aliphatic Index 16.67

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 377.76

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

6

Formula

C40H48N6O11

Mass

788.85

PI

3.29

Net Charge

-1

Boman Index

-0.71

Hydrophobicity

-0.517

Chemical_Mass

788.8408

Monoisotopic_Mass

788.3369

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Morinaga Y., Iwai K., Tomita H., Takaya, Y., Naraoka T., Matsue H.

Title Chemical nature of a new antihypertensive peptide derived from jellyfish. Food Sci. Technol. Res., 16, 333-340, 2010

Year 2010

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O InChI=1S/C40H48N6O11/c1-23(42-36(52)31(22-26-11-15-28(48)16-12-26)44-35(51)29(41)20-25-9-13-27(47)14-10-25)39(55)46-19-5-8-33(46)38(54)45-32(21-24-6-3-2-4-7-24)37(53)43-30(40(56)57)17-18-34(49)50/h2-4,6-7,9-16,23,29-33,47-48H,5,8,17-22,41H2,1H3,(H,42,52)(H,43,53)(H,44,51)(H,45,54)(H,49,50)(H,56,57)/t23-,29-,30-,31-,32-,33-/m0/s1 InChIKey: VROOLYJGVMYECU-XDGMXVDYSA-N ________________________________________

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Morinaga Y., Iwai K., Tomita H., Takaya, Y., Naraoka T., Matsue H.

Title Chemical nature of a new antihypertensive peptide derived from jellyfish. Food Sci. Technol. Res., 16, 333-340, 2010

Year 2010

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O InChI=1S/C40H48N6O11/c1-23(42-36(52)31(22-26-11-15-28(48)16-12-26)44-35(51)29(41)20-25-9-13-27(47)14-10-25)39(55)46-19-5-8-33(46)38(54)45-32(21-24-6-3-2-4-7-24)37(53)43-30(40(56)57)17-18-34(49)50/h2-4,6-7,9-16,23,29-33,47-48H,5,8,17-22,41H2,1H3,(H,42,52)(H,43,53)(H,44,51)(H,45,54)(H,49,50)(H,56,57)/t23-,29-,30-,31-,32-,33-/m0/s1 InChIKey: VROOLYJGVMYECU-XDGMXVDYSA-N ________________________________________

Number_of_Residues

6