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Peptide record

TPDB47297

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47297
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
DMIPAQK
Physicochemical Analysis
C34H59N9O11S1
RNCEGHLFSTWYV
ADQIKMP
801.96
6.75
1
1
3
-0
2.54
-0.614
70.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
1
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 1 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C34H59N9O11S1
801.96
6.75
-0
2.54
-0.614
801.9497
801.4041
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
45.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Yokoyama K., Chiba H., and Yoshikawa M.
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545, 1992
1992
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C34H59N9O11S/c1-5-18(2)27(42-31(50)22(13-16-55-4)40-29(48)20(36)17-26(45)46)33(52)43-15-8-10-24(43)32(51)38-19(3)28(47)39-21(11-12-25(37)44)30(49)41-23(34(53)54)9-6-7-14-35/h18-24,27H,5-17,35-36H2,1-4H3,(H2,37,44)(H,38,51)(H,39,47)(H,40,48)(H,41,49)(H,42,50)(H,45,46)(H,53,54)/t18-,19-,20-,21-,22-,23-,24-,27-/m0/s1 InChIKey=YWGXTHOQJQSQJK-VCFCACAUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
45.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Yokoyama K., Chiba H., and Yoshikawa M.
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545, 1992
1992
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C34H59N9O11S/c1-5-18(2)27(42-31(50)22(13-16-55-4)40-29(48)20(36)17-26(45)46)33(52)43-15-8-10-24(43)32(51)38-19(3)28(47)39-21(11-12-25(37)44)30(49)41-23(34(53)54)9-6-7-14-35/h18-24,27H,5-17,35-36H2,1-4H3,(H2,37,44)(H,38,51)(H,39,47)(H,40,48)(H,41,49)(H,42,50)(H,45,46)(H,53,54)/t18-,19-,20-,21-,22-,23-,24-,27-/m0/s1 InChIKey=YWGXTHOQJQSQJK-VCFCACAUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
7