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Peptide record

TPDB47292

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47292
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
VPQPIP
Physicochemical Analysis
C31H51N7O8
ARNDCEGHLKMFSTWY
P
649.79
6.02
0
0
2
-0
1.69
0.067
113.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C31H51N7O8
649.79
6.02
-0
1.69
0.067
649.7767
649.3787
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
290.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H51N7O8/c1-5-18(4)25(30(44)38-16-8-11-22(38)31(45)46)35-27(41)21-10-6-14-36(21)28(42)19(12-13-23(32)39)34-26(40)20-9-7-15-37(20)29(43)24(33)17(2)3/h17-22,24-25H,5-16,33H2,1-4H3,(H2,32,39)(H,34,40)(H,35,41)(H,45,46)/t18-,19-,20-,21-,22-,24-,25-/m0/s1 InChIKey: WIBGWYTZCVLUQE-MDLMHBAVSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
290.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H51N7O8/c1-5-18(4)25(30(44)38-16-8-11-22(38)31(45)46)35-27(41)21-10-6-14-36(21)28(42)19(12-13-23(32)39)34-26(40)20-9-7-15-37(20)29(43)24(33)17(2)3/h17-22,24-25H,5-16,33H2,1-4H3,(H2,32,39)(H,34,40)(H,35,41)(H,45,46)/t18-,19-,20-,21-,22-,24-,25-/m0/s1 InChIKey: WIBGWYTZCVLUQE-MDLMHBAVSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6