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Peptide record

TPDB47290

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47290
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
QPLIYP
Physicochemical Analysis
C36H55N7O9
ARNDCEGHKMFSTWV
P
729.87
5.94
0
0
3
-0
-0.33
0.050
130.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1490
204.14
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C36H55N7O9
729.87
5.94
-0
-0.33
0.050
729.8612
729.4048
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C36H55N7O9/c1-5-21(4)30(33(48)40-26(19-22-10-12-23(44)13-11-22)35(50)43-17-7-9-28(43)36(51)52)41-31(46)25(18-20(2)3)39-32(47)27-8-6-16-42(27)34(49)24(37)14-15-29(38)45/h10-13,20-21,24-28,30,44H,5-9,14-19,37H2,1-4H3,(H2,38,45)(H,39,47)(H,40,48)(H,41,46)(H,51,52)/t21-,24-,25-,26-,27-,28-,30-/m0/s1 InChIKey: UHWSXOYRCJDMLD-YYNHRMGXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
3.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C36H55N7O9/c1-5-21(4)30(33(48)40-26(19-22-10-12-23(44)13-11-22)35(50)43-17-7-9-28(43)36(51)52)41-31(46)25(18-20(2)3)39-32(47)27-8-6-16-42(27)34(49)24(37)14-15-29(38)45/h10-13,20-21,24-28,30,44H,5-9,14-19,37H2,1-4H3,(H2,38,45)(H,39,47)(H,40,48)(H,41,46)(H,51,52)/t21-,24-,25-,26-,27-,28-,30-/m0/s1 InChIKey: UHWSXOYRCJDMLD-YYNHRMGXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6