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Peptide record

TPDB47288

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47288
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PHQIYP
Physicochemical Analysis
C36H51N9O9
ARNDCEGLKMFSTWV
P
753.86
7.77
1
0
2
+0
1.19
-1.117
65.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
197.65
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
1
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C36H51N9O9
753.86
7.77
+0
1.19
-1.117
753.8430
753.3798
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
30.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]([H])(Cc1cnc[nH]1)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C36H51N9O9/c1-3-20(2)30(34(51)43-27(16-21-8-10-23(46)11-9-21)35(52)45-15-5-7-28(45)36(53)54)44-32(49)25(12-13-29(37)47)41-33(50)26(17-22-18-38-19-40-22)42-31(48)24-6-4-14-39-24/h8-11,18-20,24-28,30,39,46H,3-7,12-17H2,1-2H3,(H2,37,47)(H,38,40)(H,41,50)(H,42,48)(H,43,51)(H,44,49)(H,53,54)/t20-,24-,25-,26-,27-,28-,30-/m0/s1 InChIKey: GFNSVLLGEORVSH-XAIUJWLNSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
30.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]([H])(Cc1cnc[nH]1)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C36H51N9O9/c1-3-20(2)30(34(51)43-27(16-21-8-10-23(46)11-9-21)35(52)45-15-5-7-28(45)36(53)54)44-32(49)25(12-13-29(37)47)41-33(50)26(17-22-18-38-19-40-22)42-31(48)24-6-4-14-39-24/h8-11,18-20,24-28,30,39,46H,3-7,12-17H2,1-2H3,(H2,37,47)(H,38,40)(H,41,50)(H,42,48)(H,43,51)(H,44,49)(H,53,54)/t20-,24-,25-,26-,27-,28-,30-/m0/s1 InChIKey: GFNSVLLGEORVSH-XAIUJWLNSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6