TPDB

3D PDB MODEL

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TPDB ID TPDB47279

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

GVYPHK

FASTA

>TPDB47279|ACE inhibitors;Antihypertensive|length=6
GVYPHK

Formula C33H49N9O8

Absent Amino Acids ARNDCEQILMFSTW

Common Amino Acids GHKPYV

Mass 699.81

PI 9.74

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 1.54

Hydrophobicity -1.033

Aliphatic Index 48.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 212.92

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

1

H

0

I

0

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

6

Formula

C33H49N9O8

Mass

699.81

PI

9.74

Net Charge

+1

Boman Index

1.54

Hydrophobicity

-1.033

Chemical_Mass

699.7957

Monoisotopic_Mass

699.3693

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Karaki H., Kuwahara M., Sugano S., Doi C., Doi K., Matsumura N., Shimizu T.

Title

Oral administration of peptides derived from bonito bowels decreases blood pressure in spontaneously hypertensive rats. Comp. Biochem. Physiol., 104C, 351-

Year 1993

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCCN)(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@@]([H])(NC(=O)CN)C(C)C)C(O)=O InChI=1S/C33H49N9O8/c1-19(2)28(41-27(44)16-35)31(47)40-25(14-20-8-10-22(43)11-9-20)32(48)42-13-5-7-26(42)30(46)39-24(15-21-17-36-18-37-21)29(45)38-23(33(49)50)6-3-4-12-34/h8-11,17-19,23-26,28,43H,3-7,12-16,34-35H2,1-2H3,(H,36,37)(H,38,45)(H,39,46)(H,40,47)(H,41,44)(H,49,50)/t23-,24-,25-,26-,28-/m0/s1 InChIKey=RTKCCHKIDOPIQT-MGAMHGSISA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Karaki H., Kuwahara M., Sugano S., Doi C., Doi K., Matsumura N., Shimizu T.

Title

Oral administration of peptides derived from bonito bowels decreases blood pressure in spontaneously hypertensive rats. Comp. Biochem. Physiol., 104C, 351-

Year 1993

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCCN)(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@@]([H])(NC(=O)CN)C(C)C)C(O)=O InChI=1S/C33H49N9O8/c1-19(2)28(41-27(44)16-35)31(47)40-25(14-20-8-10-22(43)11-9-20)32(48)42-13-5-7-26(42)30(46)39-24(15-21-17-36-18-37-21)29(45)38-23(33(49)50)6-3-4-12-34/h8-11,17-19,23-26,28,43H,3-7,12-16,34-35H2,1-2H3,(H,36,37)(H,38,45)(H,39,46)(H,40,47)(H,41,44)(H,49,50)/t23-,24-,25-,26-,28-/m0/s1 InChIKey=RTKCCHKIDOPIQT-MGAMHGSISA-N

Number_of_Residues

6