Back to search

Peptide record

TPDB47264

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47264
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
YANPAVVRP
Physicochemical Analysis
C45H71N13O12
DCEQGHILKMFSTW
APV
986.14
9.88
1
0
5
+1
0.99
-0.056
86.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
151.09
2
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
9
C45H71N13O12
986.14
9.88
+1
0.99
-0.056
986.1223
985.5329
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
7.80 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C45H71N13O12/c1-22(2)34(40(65)53-29(10-7-17-50-45(48)49)42(67)58-19-9-12-32(58)44(69)70)56-41(66)35(23(3)4)55-37(62)25(6)52-39(64)31-11-8-18-57(31)43(68)30(21-33(47)60)54-36(61)24(5)51-38(63)28(46)20-26-13-15-27(59)16-14-26/h13-16,22-25,28-32,34-35,59H,7-12,17-21,46H2,1-6H3,(H2,47,60)(H,51,63)(H,52,64)(H,53,65)(H,54,61)(H,55,62)(H,56,66)(H,69,70)(H4,48,49,50)/t24-,25-,28-,29-,30-,31-,32-,34-,35-/m0/s1 InChIKey=JLEWJQXLSUBXKS-FVVXXMHZSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
7.80 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C45H71N13O12/c1-22(2)34(40(65)53-29(10-7-17-50-45(48)49)42(67)58-19-9-12-32(58)44(69)70)56-41(66)35(23(3)4)55-37(62)25(6)52-39(64)31-11-8-18-57(31)43(68)30(21-33(47)60)54-36(61)24(5)51-38(63)28(46)20-26-13-15-27(59)16-14-26/h13-16,22-25,28-32,34-35,59H,7-12,17-21,46H2,1-6H3,(H2,47,60)(H,51,63)(H,52,64)(H,53,65)(H,54,61)(H,55,62)(H,56,66)(H,69,70)(H4,48,49,50)/t24-,25-,28-,29-,30-,31-,32-,34-,35-/m0/s1 InChIKey=JLEWJQXLSUBXKS-FVVXXMHZSA-N
Additional Detail Fields 1 fields
9