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Peptide record

TPDB47262

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47262
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
FermFooDB Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
AMKPWIQPK
Physicochemical Analysis
C52H83N13O11S1
RNDCEGHLFSTYV
KP
1098.37
10.60
2
0
4
+2
0.90
-0.800
54.44
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
500.74
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
2
K
1
M
0
F
2
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 2 M: 1 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
9
C52H83N13O11S1
1098.37
10.60
+2
0.90
-0.800
1098.3587
1097.6037
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79, 1316-1321, 1996
1996
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C52H83N13O11S/c1-5-30(2)43(49(72)60-37(20-21-42(56)66)51(74)65-26-12-18-40(65)47(70)61-38(52(75)76)17-9-11-24-54)63-46(69)39(28-32-29-57-34-15-7-6-14-33(32)34)62-48(71)41-19-13-25-64(41)50(73)36(16-8-10-23-53)59-45(68)35(22-27-77-4)58-44(67)31(3)55/h6-7,14-15,29-31,35-41,43,57H,5,8-13,16-28,53-55H2,1-4H3,(H2,56,66)(H,58,67)(H,59,68)(H,60,72)(H,61,70)(H,62,71)(H,63,69)(H,75,76)/t30-,31-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 InChIKey=ODLZIMAJNVNJEX-GZCZXRBKSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79, 1316-1321, 1996
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C52H83N13O11S/c1-5-30(2)43(49(72)60-37(20-21-42(56)66)51(74)65-26-12-18-40(65)47(70)61-38(52(75)76)17-9-11-24-54)63-46(69)39(28-32-29-57-34-15-7-6-14-33(32)34)62-48(71)41-19-13-25-64(41)50(73)36(16-8-10-23-53)59-45(68)35(22-27-77-4)58-44(67)31(3)55/h6-7,14-15,29-31,35-41,43,57H,5,8-13,16-28,53-55H2,1-4H3,(H2,56,66)(H,58,67)(H,59,68)(H,60,72)(H,61,70)(H,62,71)(H,63,69)(H,75,76)/t30-,31-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 InChIKey=ODLZIMAJNVNJEX-GZCZXRBKSA-N
Additional Detail Fields 1 fields
9