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Peptide record

TPDB47260

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47260
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LVYPFP
Physicochemical Analysis
C39H54N6O8
ARNDCEQGHIKMSTW
P
734.89
5.94
0
0
4
-0
-1.66
1.050
113.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
202.75
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
6
C39H54N6O8
734.89
5.94
-0
-1.66
1.050
734.8793
734.3990
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
132.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Gonzalez-Gonzalez C., Gibson T., Jauregi P.
Novel probiotic fermented milk with angiotensin I-converting enzyme inhibitory peptides produced by Bifidobacterium bifidum MF 20/5. Int. J. Food Microbiol. 2013, 167:131-137.
2013
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C39H54N6O8/c1-23(2)20-28(40)34(47)43-33(24(3)4)36(49)42-30(22-26-14-16-27(46)17-15-26)37(50)44-18-8-12-31(44)35(48)41-29(21-25-10-6-5-7-11-25)38(51)45-19-9-13-32(45)39(52)53/h5-7,10-11,14-17,23-24,28-33,46H,8-9,12-13,18-22,40H2,1-4H3,(H,41,48)(H,42,49)(H,43,47)(H,52,53)/t28-,29-,30-,31-,32-,33-/m0/s1 InChIKey: YOZBZDNSPXFCAP-FSJACQRISA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
132.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Gonzalez-Gonzalez C., Gibson T., Jauregi P.
Novel probiotic fermented milk with angiotensin I-converting enzyme inhibitory peptides produced by Bifidobacterium bifidum MF 20/5. Int. J. Food Microbiol. 2013, 167:131-137.
2013
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C39H54N6O8/c1-23(2)20-28(40)34(47)43-33(24(3)4)36(49)42-30(22-26-14-16-27(46)17-15-26)37(50)44-18-8-12-31(44)35(48)41-29(21-25-10-6-5-7-11-25)38(51)45-19-9-13-32(45)39(52)53/h5-7,10-11,14-17,23-24,28-33,46H,8-9,12-13,18-22,40H2,1-4H3,(H,41,48)(H,42,49)(H,43,47)(H,52,53)/t28-,29-,30-,31-,32-,33-/m0/s1 InChIKey: YOZBZDNSPXFCAP-FSJACQRISA-N
Additional Detail Fields 1 fields
6