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Peptide record

TPDB47251

ACE inhibitor ACE inhibitors Antihypertensive iDPPIV standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB47251
ACE inhibitor
ACE inhibitors Antihypertensive iDPPIV
Cardiometabolic peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and iDPPIV) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LTQTPVVVPPF
Physicochemical Analysis
C58H92N12O15
ARNDCEGHIKMSWY
PV
1197.44
6.02
0
0
5
-0
0.73
0.864
114.55
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
3
P
0
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 3 S: 0 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
11
C58H92N12O15
1197.44
6.02
-0
0.73
0.864
1197.4188
1196.6783
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.36 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Quirós A., Contreras M. M., Ramos M., Amigo L., Recio I.
Stability to gastrointestinal enzymes and structure-activity relationship of β-casein-peptides with antihypertensive properties. Peptides, 2009, 30:1848-1853.
2009
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C58H92N12O15/c1-29(2)27-36(59)48(74)66-46(33(9)71)54(80)61-37(22-23-42(60)73)49(75)67-47(34(10)72)57(83)69-25-15-20-40(69)51(77)63-43(30(3)4)52(78)64-44(31(5)6)53(79)65-45(32(7)8)56(82)70-26-16-21-41(70)55(81)68-24-14-19-39(68)50(76)62-38(58(84)85)28-35-17-12-11-13-18-35/h11-13,17-18,29-34,36-41,43-47,71-72H,14-16,19-28,59H2,1-10H3,(H2,60,73)(H,61,80)(H,62,76)(H,63,77)(H,64,78)(H,65,79)(H,66,74)(H,67,75)(H,84,85)/t33-,34-,36+,37+,38+,39+,40+,41+,43+,44+,45+,46+,47+/m1/s1 InChIKey: WHVRIIHQDFXLFY-PSQVKVLZSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.36 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Quirós A., Contreras M. M., Ramos M., Amigo L., Recio I.
Stability to gastrointestinal enzymes and structure-activity relationship of β-casein-peptides with antihypertensive properties. Peptides, 2009, 30:1848-1853.
2009
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C58H92N12O15/c1-29(2)27-36(59)48(74)66-46(33(9)71)54(80)61-37(22-23-42(60)73)49(75)67-47(34(10)72)57(83)69-25-15-20-40(69)51(77)63-43(30(3)4)52(78)64-44(31(5)6)53(79)65-45(32(7)8)56(82)70-26-16-21-41(70)55(81)68-24-14-19-39(68)50(76)62-38(58(84)85)28-35-17-12-11-13-18-35/h11-13,17-18,29-34,36-41,43-47,71-72H,14-16,19-28,59H2,1-10H3,(H2,60,73)(H,61,80)(H,62,76)(H,63,77)(H,64,78)(H,65,79)(H,66,74)(H,67,75)(H,84,85)/t33-,34-,36+,37+,38+,39+,40+,41+,43+,44+,45+,46+,47+/m1/s1 InChIKey: WHVRIIHQDFXLFY-PSQVKVLZSA-N
Additional Detail Fields 1 fields
11