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Peptide record

TPDB47230

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47230
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LNNSRAP
Physicochemical Analysis
C31H54N12O11
DCEQGHIKMFTWYV
N
770.84
11.05
1
0
2
+1
1.50
-1.186
70.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
1
R
2
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C31H54N12O11
770.84
11.05
+1
1.50
-1.186
770.8321
770.4023
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
105.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Ruiz-Giménez P., Salom J. B., Marcos J. F., Valles S., Martinez-Maqueda D., Recio I., Torregrosa G., Alborch E., Manzanares P.
Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides. Food Chem., 131, 266-273, 2012
2012
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C31H54N12O11/c1-14(2)10-16(32)24(47)40-18(11-22(33)45)26(49)41-19(12-23(34)46)27(50)42-20(13-44)28(51)39-17(6-4-8-37-31(35)36)25(48)38-15(3)29(52)43-9-5-7-21(43)30(53)54/h14-21,44H,4-13,32H2,1-3H3,(H2,33,45)(H2,34,46)(H,38,48)(H,39,51)(H,40,47)(H,41,49)(H,42,50)(H,53,54)(H4,35,36,37)/t15-,16-,17-,18-,19-,20-,21-/m0/s1 InChIKey: WYPUBMUVBADNFB-BPSSIEEOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
105.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Ruiz-Giménez P., Salom J. B., Marcos J. F., Valles S., Martinez-Maqueda D., Recio I., Torregrosa G., Alborch E., Manzanares P.
Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides. Food Chem., 131, 266-273, 2012
2012
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C31H54N12O11/c1-14(2)10-16(32)24(47)40-18(11-22(33)45)26(49)41-19(12-23(34)46)27(50)42-20(13-44)28(51)39-17(6-4-8-37-31(35)36)25(48)38-15(3)29(52)43-9-5-7-21(43)30(53)54/h14-21,44H,4-13,32H2,1-3H3,(H2,33,45)(H2,34,46)(H,38,48)(H,39,51)(H,40,47)(H,41,49)(H,42,50)(H,53,54)(H4,35,36,37)/t15-,16-,17-,18-,19-,20-,21-/m0/s1 InChIKey: WYPUBMUVBADNFB-BPSSIEEOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7