TPDB

3D PDB MODEL

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TPDB ID TPDB47222

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and iDPPIV) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.

Sequence

MAIPPK

FASTA

>TPDB47222|ACE inhibitors;Antihypertensive;iDPPIV|length=6
MAIPPK

Formula C30H53N7O7S1

Absent Amino Acids RNDCEQGHLFSTWYV

Common Amino Acids P

Mass 655.85

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 1.18

Hydrophobicity 0.183

Aliphatic Index 81.67

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

1

K

1

M

0

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 1 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C30H53N7O7S1

Mass

655.85

PI

10.10

Net Charge

+1

Boman Index

1.18

Hydrophobicity

0.183

Chemical_Mass

655.8485

Monoisotopic_Mass

655.3715

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Manso M. A., López-Fandiño R.

Title

Angiotensin I converting enzyme-inhibitory activity of bovine, ovine, and caprine kappa-casein macropeptides and their tryptic hydrolysates. J. Food Prot., 66, 1686-1692, 2003

Year 2003

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C30H53N7O7S/c1-5-18(2)24(35-25(38)19(3)33-26(39)20(32)13-17-45-4)29(42)37-16-9-12-23(37)28(41)36-15-8-11-22(36)27(40)34-21(30(43)44)10-6-7-14-31/h18-24H,5-17,31-32H2,1-4H3,(H,33,39)(H,34,40)(H,35,38)(H,43,44)/t18-,19-,20-,21-,22-,23-,24-/m0/s1 InChIKey=CSPBULXTZDBZNA-LQDRYOBXSA-N Antithrombotic peptide according to the BIOPEP-UWM database (ID 3293)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Manso M. A., López-Fandiño R.

Title

Angiotensin I converting enzyme-inhibitory activity of bovine, ovine, and caprine kappa-casein macropeptides and their tryptic hydrolysates. J. Food Prot., 66, 1686-1692, 2003

Year 2003

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C30H53N7O7S/c1-5-18(2)24(35-25(38)19(3)33-26(39)20(32)13-17-45-4)29(42)37-16-9-12-23(37)28(41)36-15-8-11-22(36)27(40)34-21(30(43)44)10-6-7-14-31/h18-24H,5-17,31-32H2,1-4H3,(H,33,39)(H,34,40)(H,35,38)(H,43,44)/t18-,19-,20-,21-,22-,23-,24-/m0/s1 InChIKey=CSPBULXTZDBZNA-LQDRYOBXSA-N Antithrombotic peptide according to the BIOPEP-UWM database (ID 3293)

Number_of_Residues

6