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Peptide record

TPDB47214

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47214
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
WPERPPQIP
Physicochemical Analysis
C53H78N14O13
ANDCGHLKMFSTYV
P
1119.29
6.97
1
1
2
-0
3.05
-1.589
43.33
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
491.38
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
4
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 4 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
9
C53H78N14O13
1119.29
6.97
-0
3.05
-1.589
1119.2693
1118.5855
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
22.93 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Liu M., Du M., Zhang Y., Xu W., Wang C., Wang K., Zhang L.
Purification and identification of an ACE inhibitory peptide from walnut protein. J. Agric. Food Chem., 61, 4097-4100, 2013
2013
Journal

Other

9
BIOPEP-UWM database of bioactive peptides: SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N4[C@@H](CCC4)C(=O)N5[C@@H](CCC5)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@H](CC)C)C(=O)N6[C@@H](CCC6)C(=O)O InChI=1S/C53H78N14O13/c1-3-29(2)43(51(78)67-26-10-17-40(67)52(79)80)63-45(72)34(18-20-41(55)68)60-47(74)38-15-8-24-65(38)50(77)39-16-9-25-66(39)49(76)36(13-6-22-58-53(56)57)62-44(71)35(19-21-42(69)70)61-46(73)37-14-7-23-64(37)48(75)32(54)27-30-28-59-33-12-5-4-11-31(30)33/h4-5,11-12,28-29,32,34-40,43,59H,3,6-10,13-27,54H2,1-2H3,(H2,55,68)(H,60,74)(H,61,73)(H,62,71)(H,63,72)(H,69,70)(H,79,80)(H4,56,57,58)/t29-,32-,34-,35-,36-,37-,38-,39-,40-,43-/m0/s1 InChIKey=APBMTKMZPRHCJC-AXPLDACSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
22.93 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Liu M., Du M., Zhang Y., Xu W., Wang C., Wang K., Zhang L.
Purification and identification of an ACE inhibitory peptide from walnut protein. J. Agric. Food Chem., 61, 4097-4100, 2013
2013
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides: SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N4[C@@H](CCC4)C(=O)N5[C@@H](CCC5)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@H](CC)C)C(=O)N6[C@@H](CCC6)C(=O)O InChI=1S/C53H78N14O13/c1-3-29(2)43(51(78)67-26-10-17-40(67)52(79)80)63-45(72)34(18-20-41(55)68)60-47(74)38-15-8-24-65(38)50(77)39-16-9-25-66(39)49(76)36(13-6-22-58-53(56)57)62-44(71)35(19-21-42(69)70)61-46(73)37-14-7-23-64(37)48(75)32(54)27-30-28-59-33-12-5-4-11-31(30)33/h4-5,11-12,28-29,32,34-40,43,59H,3,6-10,13-27,54H2,1-2H3,(H2,55,68)(H,60,74)(H,61,73)(H,62,71)(H,63,72)(H,69,70)(H,79,80)(H4,56,57,58)/t29-,32-,34-,35-,36-,37-,38-,39-,40-,43-/m0/s1 InChIKey=APBMTKMZPRHCJC-AXPLDACSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Additional Detail Fields 1 fields
9