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Peptide record

TPDB47208

ACE inhibitor from beta-CN (180-197) ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47208
ACE inhibitor from beta-CN (180-197)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
YPQRDMPIQ
Physicochemical Analysis
C50H78N14O15S1
ANCEGHLKFSTWV
QP
1147.31
6.71
1
1
3
-0
2.62
-1.456
43.33
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
129.87
3
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
2
Q
0
G
0
H
1
I
0
L
0
K
1
M
0
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C50H78N14O15S1
1147.31
6.71
-0
2.62
-1.456
1147.3021
1146.5474
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Hayes M., Stanton C., Fitzgerald G.F., Ross R.P.
Putting microbes to work: Dairy fermentation, cell factories and bioactive peptides. Part II: Bioactive peptide functions. Biotechnol. J., 2 (2007), 435–449.
2007
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O InChI=1S/C50H78N14O15S/c1-4-26(2)40(46(75)60-33(49(78)79)16-18-38(53)67)62-45(74)36-10-7-22-64(36)48(77)32(19-23-80-3)59-43(72)34(25-39(68)69)61-41(70)30(8-5-20-56-50(54)55)57-42(71)31(15-17-37(52)66)58-44(73)35-9-6-21-63(35)47(76)29(51)24-27-11-13-28(65)14-12-27/h11-14,26,29-36,40,65H,4-10,15-25,51H2,1-3H3,(H2,52,66)(H2,53,67)(H,57,71)(H,58,73)(H,59,72)(H,60,75)(H,61,70)(H,62,74)(H,68,69)(H,78,79)(H4,54,55,56)/t26-,29-,30-,31-,32-,33-,34-,35-,36-,40-/m0/s1 InChIKey=UHYJERVGFPBRDH-XTPZLQNTSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hayes M., Stanton C., Fitzgerald G.F., Ross R.P.
Putting microbes to work: Dairy fermentation, cell factories and bioactive peptides. Part II: Bioactive peptide functions. Biotechnol. J., 2 (2007), 435–449.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O InChI=1S/C50H78N14O15S/c1-4-26(2)40(46(75)60-33(49(78)79)16-18-38(53)67)62-45(74)36-10-7-22-64(36)48(77)32(19-23-80-3)59-43(72)34(25-39(68)69)61-41(70)30(8-5-20-56-50(54)55)57-42(71)31(15-17-37(52)66)58-44(73)35-9-6-21-63(35)47(76)29(51)24-27-11-13-28(65)14-12-27/h11-14,26,29-36,40,65H,4-10,15-25,51H2,1-3H3,(H2,52,66)(H2,53,67)(H,57,71)(H,58,73)(H,59,72)(H,60,75)(H,61,70)(H,62,74)(H,68,69)(H,78,79)(H4,54,55,56)/t26-,29-,30-,31-,32-,33-,34-,35-,36-,40-/m0/s1 InChIKey=UHYJERVGFPBRDH-XTPZLQNTSA-N
Additional Detail Fields 1 fields
9