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Peptide record

TPDB47201

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB47201
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LVYPFPGPIH
Physicochemical Analysis
C58H82N12O12
ARNDCEQKMSTW
P
1139.36
7.77
1
0
5
+0
-0.55
0.560
107.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
130.77
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
1
L
0
K
0
M
1
F
3
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
10
C58H82N12O12
1139.36
7.77
+0
-0.55
0.560
1139.3416
1138.6156
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
89.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Pihlanto A., Virtanen T., Korhonen H.
Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effect of fermented milk. Int. Dairy J. 2010 20:3-10.
2010
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(O)=O InChI=1S/C58H82N12O12/c1-7-35(6)49(55(78)65-43(58(81)82)29-38-30-60-32-62-38)67-53(76)45-17-11-23-68(45)47(72)31-61-51(74)44-16-12-24-69(44)56(79)41(27-36-14-9-8-10-15-36)63-52(75)46-18-13-25-70(46)57(80)42(28-37-19-21-39(71)22-20-37)64-54(77)48(34(4)5)66-50(73)40(59)26-33(2)3/h8-10,14-15,19-22,30,32-35,40-46,48-49,71H,7,11-13,16-18,23-29,31,59H2,1-6H3,(H,60,62)(H,61,74)(H,63,75)(H,64,77)(H,65,78)(H,66,73)(H,67,76)(H,81,82)/t35-,40-,41-,42-,43-,44-,45-,46-,48-,49-/m0/s1 InChIKey: PMCNOPFGOOIQMB-KRYSDLGTSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
89.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto A., Virtanen T., Korhonen H.
Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effect of fermented milk. Int. Dairy J. 2010 20:3-10.
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(O)=O InChI=1S/C58H82N12O12/c1-7-35(6)49(55(78)65-43(58(81)82)29-38-30-60-32-62-38)67-53(76)45-17-11-23-68(45)47(72)31-61-51(74)44-16-12-24-69(44)56(79)41(27-36-14-9-8-10-15-36)63-52(75)46-18-13-25-70(46)57(80)42(28-37-19-21-39(71)22-20-37)64-54(77)48(34(4)5)66-50(73)40(59)26-33(2)3/h8-10,14-15,19-22,30,32-35,40-46,48-49,71H,7,11-13,16-18,23-29,31,59H2,1-6H3,(H,60,62)(H,61,74)(H,63,75)(H,64,77)(H,65,78)(H,66,73)(H,67,76)(H,81,82)/t35-,40-,41-,42-,43-,44-,45-,46-,48-,49-/m0/s1 InChIKey: PMCNOPFGOOIQMB-KRYSDLGTSA-N
Additional Detail Fields 1 fields
10