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Peptide record

TPDB47189

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47189
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
ENLHLPLP
Physicochemical Analysis
C43H69N11O12
ARDCQGIKMFSTWYV
L
932.09
5.13
1
1
3
-1
2.62
-0.250
146.25
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
1
H
0
I
3
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 3 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C43H69N11O12
932.09
5.13
-1
2.62
-0.250
932.0717
931.5111
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
155.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C[N]1[H])C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(O)=O InChI=1S/C43H69N11O12/c1-22(2)15-27(49-39(61)29(19-34(45)55)48-36(58)26(44)11-12-35(56)57)37(59)50-28(18-25-20-46-21-47-25)38(60)51-30(16-23(3)4)41(63)53-13-7-9-32(53)40(62)52-31(17-24(5)6)42(64)54-14-8-10-33(54)43(65)66/h20-24,26-33H,7-19,44H2,1-6H3,(H2,45,55)(H,46,47)(H,48,58)(H,49,61)(H,50,59)(H,51,60)(H,52,62)(H,56,57)(H,65,66)/t26-,27-,28-,29-,30-,31-,32-,33-/m0/s1 InChIKey: WMYCAJATMIEXMG-DKTXOJPGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
155.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C[N]1[H])C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(O)=O InChI=1S/C43H69N11O12/c1-22(2)15-27(49-39(61)29(19-34(45)55)48-36(58)26(44)11-12-35(56)57)37(59)50-28(18-25-20-46-21-47-25)38(60)51-30(16-23(3)4)41(63)53-13-7-9-32(53)40(62)52-31(17-24(5)6)42(64)54-14-8-10-33(54)43(65)66/h20-24,26-33H,7-19,44H2,1-6H3,(H2,45,55)(H,46,47)(H,48,58)(H,49,61)(H,50,59)(H,51,60)(H,52,62)(H,56,57)(H,65,66)/t26-,27-,28-,29-,30-,31-,32-,33-/m0/s1 InChIKey: WMYCAJATMIEXMG-DKTXOJPGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
8