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Peptide record

TPDB47188

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47188
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
NLHLPLP
Physicochemical Analysis
C38H62N10O9
ARDCEQGIKMFSTWYV
L
802.97
7.85
1
0
3
+0
0.60
0.214
167.14
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
3
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 3 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C38H62N10O9
802.97
7.85
+0
0.60
0.214
802.9580
802.4687
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
51.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C[N]1[H])C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(O)=O InChI=1S/C38H62N10O9/c1-20(2)13-25(43-32(50)24(39)17-31(40)49)33(51)44-26(16-23-18-41-19-42-23)34(52)45-27(14-21(3)4)36(54)47-11-7-9-29(47)35(53)46-28(15-22(5)6)37(55)48-12-8-10-30(48)38(56)57/h18-22,24-30H,7-17,39H2,1-6H3,(H2,40,49)(H,41,42)(H,43,50)(H,44,51)(H,45,52)(H,46,53)(H,56,57)/t24-,25-,26-,27-,28-,29-,30-/m0/s1 InChIKey: BJUQASBWAWJAGZ-FLMSMKGQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
51.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C[N]1[H])C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(O)=O InChI=1S/C38H62N10O9/c1-20(2)13-25(43-32(50)24(39)17-31(40)49)33(51)44-26(16-23-18-41-19-42-23)34(52)45-27(14-21(3)4)36(54)47-11-7-9-29(47)35(53)46-28(15-22(5)6)37(55)48-12-8-10-30(48)38(56)57/h18-22,24-30H,7-17,39H2,1-6H3,(H2,40,49)(H,41,42)(H,43,50)(H,44,51)(H,45,52)(H,46,53)(H,56,57)/t24-,25-,26-,27-,28-,29-,30-/m0/s1 InChIKey: BJUQASBWAWJAGZ-FLMSMKGQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7