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Peptide record

TPDB47187

ACE inhibitor (from bovine b-CN) ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47187
ACE inhibitor (from bovine b-CN)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
VYPFPGPI
Physicochemical Analysis
C46H64N8O10
ARNDCEQHLKMSTW
P
889.06
5.94
0
0
4
-0
-0.95
0.625
85.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
167.59
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
1
F
3
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
8
C46H64N8O10
889.06
5.94
-0
-0.95
0.625
889.0454
888.4730
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
500.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Van der Ven C.
Biochemical and functional characterisation of casein and whey protein hydrolysates. A study on correlations between biochemical and functional properties using multivariate data analysis. Ph.D. thesis Wageningen University, The Netherlands, 2002
2002
dissertation

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(O)=O InChI=1S/C46H64N8O10/c1-5-28(4)39(46(63)64)51-42(59)35-15-9-21-52(35)37(56)26-48-40(57)34-14-10-22-53(34)44(61)32(24-29-12-7-6-8-13-29)49-41(58)36-16-11-23-54(36)45(62)33(50-43(60)38(47)27(2)3)25-30-17-19-31(55)20-18-30/h6-8,12-13,17-20,27-28,32-36,38-39,55H,5,9-11,14-16,21-26,47H2,1-4H3,(H,48,57)(H,49,58)(H,50,60)(H,51,59)(H,63,64)/t28-,32-,33-,34-,35-,36-,38-,39-/m0/s1 InChIKey: MJFASUNIWIJBFR-YIUNQBEOSA-N Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP database of bioactive peptides, EROP-Moscow database, MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
500.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Van der Ven C.
Biochemical and functional characterisation of casein and whey protein hydrolysates. A study on correlations between biochemical and functional properties using multivariate data analysis. Ph.D. thesis Wageningen University, The Netherlands, 2002
2002
dissertation

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(O)=O InChI=1S/C46H64N8O10/c1-5-28(4)39(46(63)64)51-42(59)35-15-9-21-52(35)37(56)26-48-40(57)34-14-10-22-53(34)44(61)32(24-29-12-7-6-8-13-29)49-41(58)36-16-11-23-54(36)45(62)33(50-43(60)38(47)27(2)3)25-30-17-19-31(55)20-18-30/h6-8,12-13,17-20,27-28,32-36,38-39,55H,5,9-11,14-16,21-26,47H2,1-4H3,(H,48,57)(H,49,58)(H,50,60)(H,51,59)(H,63,64)/t28-,32-,33-,34-,35-,36-,38-,39-/m0/s1 InChIKey: MJFASUNIWIJBFR-YIUNQBEOSA-N Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP database of bioactive peptides, EROP-Moscow database, MBPDB database
Additional Detail Fields 1 fields
8