TPDB

3D PDB MODEL

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TPDB ID TPDB47161

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

ACE inhibitors Antihypertensive iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

FermFooDB Peptipedia AHTPDB AHTpin iDPPIV pep-lab

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and iDPPIV) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

LPQNIPPL

FASTA

>TPDB47161|ACE inhibitors;Antihypertensive;iDPPIV|length=8
LPQNIPPL

Formula C42H70N10O11

Absent Amino Acids ARDCEGHKMFSTWYV

Common Amino Acids P

Mass 891.08

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index 0.92

Hydrophobicity 0.037

Aliphatic Index 146.25

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

1

N

0

D

0

C

0

E

1

Q

0

G

0

H

1

I

2

L

0

K

0

M

0

F

3

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

8

Formula

C42H70N10O11

Mass

891.08

PI

6.02

Net Charge

-0

Boman Index

0.92

Hydrophobicity

0.037

Chemical_Mass

891.0628

Monoisotopic_Mass

890.5209

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 4.60 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Uenishi H., Kabuki T., Seto Y., Serizawa A., Nakajima H.

Title

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. International Dairy Journal, 2012, 22, 24-30.

Year 2012

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C42H70N10O11/c1-7-24(6)34(41(61)52-18-10-13-31(52)40(60)51-17-9-12-30(51)38(58)48-28(42(62)63)20-23(4)5)49-36(56)27(21-33(45)54)47-35(55)26(14-15-32(44)53)46-37(57)29-11-8-16-50(29)39(59)25(43)19-22(2)3/h22-31,34H,7-21,43H2,1-6H3,(H2,44,53)(H2,45,54)(H,46,57)(H,47,55)(H,48,58)(H,49,56)(H,62,63)/t24-,25-,26-,27-,28-,29-,30-,31-,34-/m0/s1 InChIKey: MGFYOVDWEVJBGE-JSPIMOTESA-N

Number_of_Residues

8