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Peptide record

TPDB47158

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47158
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
KRQKYDI
Physicochemical Analysis
C42H71N13O12
ANCEGHLMFPSTWV
K
950.11
10.19
3
1
2
+2
3.35
-2.300
55.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
156.82
2
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C42H71N13O12
950.11
10.19
+2
3.35
-2.300
950.0902
949.5329
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
26.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Katayama K., Anggraeni H. E., Mori T., Ahmed A. M., Kawahara S., Sugiyama M., Nakayama T., Maruyama M., Muguruma M.
Porcine skeletal muscle troponin is a good source of peptides with angiotensin-I converting enzyme inhibitory activity and antihypertensive effects in spontaneously hypertensive rats. J. Agric. Food Chem., 56, 355-360, 2008
2008
Journal

Other

7
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Evidence 2 Activity

Activity

IC50
Antihypertensive
26.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Katayama K., Anggraeni H. E., Mori T., Ahmed A. M., Kawahara S., Sugiyama M., Nakayama T., Maruyama M., Muguruma M.
Porcine skeletal muscle troponin is a good source of peptides with angiotensin-I converting enzyme inhibitory activity and antihypertensive effects in spontaneously hypertensive rats. J. Agric. Food Chem., 56, 355-360, 2008
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Additional Detail Fields 1 fields
7