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Peptide record

TPDB47152

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47152
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
KGYGGVSL
Physicochemical Analysis
C35H57N9O11
ARNDCEQHIMFPTW
G
779.89
9.74
1
0
3
+1
-0.28
0.100
85.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
191.05
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
8
C35H57N9O11
779.89
9.74
+1
-0.28
0.100
779.8785
779.4164
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
253.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C35H57N9O11/c1-19(2)13-25(35(54)55)42-33(52)26(18-45)43-34(53)30(20(3)4)44-29(49)16-38-27(47)15-40-32(51)24(14-21-8-10-22(46)11-9-21)41-28(48)17-39-31(50)23(37)7-5-6-12-36/h8-11,19-20,23-26,30,45-46H,5-7,12-18,36-37H2,1-4H3,(H,38,47)(H,39,50)(H,40,51)(H,41,48)(H,42,52)(H,43,53)(H,44,49)(H,54,55)/t23-,24-,25-,26-,30-/m0/s1 InChIKey: SWMAXAAOPLGWOO-WZFWIWBTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
253.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C35H57N9O11/c1-19(2)13-25(35(54)55)42-33(52)26(18-45)43-34(53)30(20(3)4)44-29(49)16-38-27(47)15-40-32(51)24(14-21-8-10-22(46)11-9-21)41-28(48)17-39-31(50)23(37)7-5-6-12-36/h8-11,19-20,23-26,30,45-46H,5-7,12-18,36-37H2,1-4H3,(H,38,47)(H,39,50)(H,40,51)(H,41,48)(H,42,52)(H,43,53)(H,44,49)(H,54,55)/t23-,24-,25-,26-,30-/m0/s1 InChIKey: SWMAXAAOPLGWOO-WZFWIWBTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
8