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Peptide record

TPDB47151

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB47151
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
MNVKHWPWMK
Physicochemical Analysis
C64H93N17O12S2
ARDCEQGILFSTY
KMW
1356.67
10.60
3
0
5
+2
-0.28
-0.990
29.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
810.81
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
2
K
2
M
0
F
1
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 2 M: 2 F: 0 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
10
C64H93N17O12S2
1356.67
10.60
+2
-0.28
-0.990
1356.6584
1355.6611
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
228.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S.
Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436, 2010
2010
book

Other

10
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
228.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S.
Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436, 2010
2010
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
10