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Peptide record

TPDB47146

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47146
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VVVPPF
Physicochemical Analysis
C34H52N6O7
ARNDCEQGHILKMSTWY
V
656.82
6.02
0
0
4
-0
-0.02
2.033
145.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
6
C34H52N6O7
656.82
6.02
-0
-0.02
2.033
656.8106
656.3885
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
1.18 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Quirós A., Contreras M. M., Ramos M., Amigo L., Recio I.
Stability to gastrointestinal enzymes and structure-activity relationship of β-casein-peptides with antihypertensive properties. Peptides. 2009, 30:1848-1853.
2009
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C34H52N6O7/c1-19(2)26(35)30(42)37-27(20(3)4)31(43)38-28(21(5)6)33(45)40-17-11-15-25(40)32(44)39-16-10-14-24(39)29(41)36-23(34(46)47)18-22-12-8-7-9-13-22/h7-9,12-13,19-21,23-28H,10-11,14-18,35H2,1-6H3,(H,36,41)(H,37,42)(H,38,43)(H,46,47)/t23-,24-,25-,26-,27-,28-/m0/s1 InChIKey: JSZQEWKLZMKMKS-QUQVWLGBSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
1.18 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Quirós A., Contreras M. M., Ramos M., Amigo L., Recio I.
Stability to gastrointestinal enzymes and structure-activity relationship of β-casein-peptides with antihypertensive properties. Peptides. 2009, 30:1848-1853.
2009
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C34H52N6O7/c1-19(2)26(35)30(42)37-27(20(3)4)31(43)38-28(21(5)6)33(45)40-17-11-15-25(40)32(44)39-16-10-14-24(39)29(41)36-23(34(46)47)18-22-12-8-7-9-13-22/h7-9,12-13,19-21,23-28H,10-11,14-18,35H2,1-6H3,(H,36,41)(H,37,42)(H,38,43)(H,46,47)/t23-,24-,25-,26-,27-,28-/m0/s1 InChIKey: JSZQEWKLZMKMKS-QUQVWLGBSA-N
Additional Detail Fields 1 fields
6