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Peptide record

TPDB47145

ACE inhibitor from b-CN (191-197) ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47145
ACE inhibitor from b-CN (191-197)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LLYQQPV
Physicochemical Analysis
C41H65N9O11
ARNDCEGHIKMFSTW
QL
860.02
5.94
0
0
4
-0
-0.38
0.271
152.86
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
173.25
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
7
C41H65N9O11
860.02
5.94
-0
-0.38
0.271
860.0059
859.4788
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1001.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C41H65N9O11/c1-21(2)18-26(42)35(54)47-29(19-22(3)4)37(56)48-30(20-24-9-11-25(51)12-10-24)38(57)45-27(13-15-32(43)52)36(55)46-28(14-16-33(44)53)40(59)50-17-7-8-31(50)39(58)49-34(23(5)6)41(60)61/h9-12,21-23,26-31,34,51H,7-8,13-20,42H2,1-6H3,(H2,43,52)(H2,44,53)(H,45,57)(H,46,55)(H,47,54)(H,48,56)(H,49,58)(H,60,61)/t26-,27-,28-,29-,30-,31-,34-/m0/s1 InChIKey=XAUNJFUFZVSUKN-LOIOPFQMSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
1001.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C41H65N9O11/c1-21(2)18-26(42)35(54)47-29(19-22(3)4)37(56)48-30(20-24-9-11-25(51)12-10-24)38(57)45-27(13-15-32(43)52)36(55)46-28(14-16-33(44)53)40(59)50-17-7-8-31(50)39(58)49-34(23(5)6)41(60)61/h9-12,21-23,26-31,34,51H,7-8,13-20,42H2,1-6H3,(H2,43,52)(H2,44,53)(H,45,57)(H,46,55)(H,47,54)(H,48,56)(H,49,58)(H,60,61)/t26-,27-,28-,29-,30-,31-,34-/m0/s1 InChIKey=XAUNJFUFZVSUKN-LOIOPFQMSA-N
Additional Detail Fields 1 fields
7