TPDB

3D PDB MODEL

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TPDB ID TPDB47142

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

YSQQQQ

FASTA

>TPDB47142|ACE inhibitors;Antihypertensive|length=6
YSQQQQ

Formula C32H48N10O13

Absent Amino Acids ARNDCEGHILKMFPTWV

Common Amino Acids Q

Mass 780.79

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index 1.51

Hydrophobicity -2.683

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 190.83

Polar Residues 6

number

0

A

0

R

0

N

0

D

0

C

0

E

4

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 4 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

6

Formula

C32H48N10O13

Mass

780.79

PI

5.94

Net Charge

-0

Boman Index

1.51

Hydrophobicity

-2.683

Chemical_Mass

780.7808

Monoisotopic_Mass

780.3391

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 860.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Yano S., Suzuki K., Funatsu G.

Title

Isolation from a-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem.60(4),661-663(1996)

Year 1996

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C32H48N10O13/c33-17(13-15-1-3-16(44)4-2-15)27(49)42-22(14-43)31(53)40-19(6-10-24(35)46)29(51)38-18(5-9-23(34)45)28(50)39-20(7-11-25(36)47)30(52)41-21(32(54)55)8-12-26(37)48/h1-4,17-22,43-44H,5-14,33H2,(H2,34,45)(H2,35,46)(H2,36,47)(H2,37,48)(H,38,51)(H,39,50)(H,40,53)(H,41,52)(H,42,49)(H,54,55)/t17-,18-,19-,20-,21-,22-/m0/s1 InChIKey=HMFIMNPHNZAKCT-WLNPFYQQSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 860.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Yano S., Suzuki K., Funatsu G.

Title

Isolation from a-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem.60(4),661-663(1996)

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C32H48N10O13/c33-17(13-15-1-3-16(44)4-2-15)27(49)42-22(14-43)31(53)40-19(6-10-24(35)46)29(51)38-18(5-9-23(34)45)28(50)39-20(7-11-25(36)47)30(52)41-21(32(54)55)8-12-26(37)48/h1-4,17-22,43-44H,5-14,33H2,(H2,34,45)(H2,35,46)(H2,36,47)(H2,37,48)(H,38,51)(H,39,50)(H,40,53)(H,41,52)(H,42,49)(H,54,55)/t17-,18-,19-,20-,21-,22-/m0/s1 InChIKey=HMFIMNPHNZAKCT-WLNPFYQQSA-N

Number_of_Residues

6