Back to search

Peptide record

TPDB47141

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47141
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PQEVLP
Physicochemical Analysis
C31H51N7O10
ARNDCGHIKMFSTWY
P
681.79
3.29
0
1
2
-1
3.01
-0.367
113.33
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C31H51N7O10
681.79
3.29
-1
3.01
-0.367
681.7755
681.3685
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
910.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C31H51N7O10/c1-16(2)15-21(30(46)38-14-6-8-22(38)31(47)48)36-29(45)25(17(3)4)37-28(44)20(10-12-24(40)41)35-27(43)19(9-11-23(32)39)34-26(42)18-7-5-13-33-18/h16-22,25,33H,5-15H2,1-4H3,(H2,32,39)(H,34,42)(H,35,43)(H,36,45)(H,37,44)(H,40,41)(H,47,48)/t18-,19-,20-,21-,22-,25-/m0/s1 InChIKey: OZCQYXRZCREFGX-GAJBLSCZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
910.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C31H51N7O10/c1-16(2)15-21(30(46)38-14-6-8-22(38)31(47)48)36-29(45)25(17(3)4)37-28(44)20(10-12-24(40)41)35-27(43)19(9-11-23(32)39)34-26(42)18-7-5-13-33-18/h16-22,25,33H,5-15H2,1-4H3,(H2,32,39)(H,34,42)(H,35,43)(H,36,45)(H,37,44)(H,40,41)(H,47,48)/t18-,19-,20-,21-,22-,25-/m0/s1 InChIKey: OZCQYXRZCREFGX-GAJBLSCZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6