TPDB

3D PDB MODEL

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TPDB ID TPDB47138

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive Bitter iDPPIV

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides

Database_Source

FermFooDB pep-lab Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.

Sequence

VRGPFP

FASTA

>TPDB47138|ACE inhibitors;Antihypertensive;Bitter;iDPPIV|length=6
VRGPFP

Formula C32H49N9O7

Absent Amino Acids ANDCEQHILKMSTWY

Common Amino Acids P

Mass 671.80

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 0.66

Hydrophobicity -0.183

Aliphatic Index 48.33

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

6

Formula

C32H49N9O7

Mass

671.80

PI

11.05

Net Charge

+1

Boman Index

0.66

Hydrophobicity

-0.183

Chemical_Mass

671.7856

Monoisotopic_Mass

671.3744

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 592.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Gómez-Ruiz J. Á., Ramos M., Recio I.

Title

Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int. Dairy J., 12, 697-706, 2002

Year 2002

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C32H49N9O7/c1-19(2)26(33)29(45)38-21(11-6-14-36-32(34)35)27(43)37-18-25(42)40-15-7-12-23(40)28(44)39-22(17-20-9-4-3-5-10-20)30(46)41-16-8-13-24(41)31(47)48/h3-5,9-10,19,21-24,26H,6-8,11-18,33H2,1-2H3,(H,37,43)(H,38,45)(H,39,44)(H,47,48)(H4,34,35,36)/t21-,22-,23-,24-,26-/m0/s1 InChIKey=PNYMARUNMYYKBV-LENLALOCSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 592.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB FermFooDB

Authors Gómez-Ruiz J. Á., Ramos M., Recio I.

Title

Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int. Dairy J., 12, 697-706, 2002

Year 2002

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C32H49N9O7/c1-19(2)26(33)29(45)38-21(11-6-14-36-32(34)35)27(43)37-18-25(42)40-15-7-12-23(40)28(44)39-22(17-20-9-4-3-5-10-20)30(46)41-16-8-13-24(41)31(47)48/h3-5,9-10,19,21-24,26H,6-8,11-18,33H2,1-2H3,(H,37,43)(H,38,45)(H,39,44)(H,47,48)(H4,34,35,36)/t21-,22-,23-,24-,26-/m0/s1 InChIKey=PNYMARUNMYYKBV-LENLALOCSA-N

Number_of_Residues

6