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Peptide record

TPDB47134

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47134
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
VLPYPV
Physicochemical Analysis
C35H54N6O8
ARNDCEQGHIKMFSTW
PV
686.85
5.94
0
0
4
-0
-0.46
1.283
161.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
216.93
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
6
C35H54N6O8
686.85
5.94
-0
-0.46
1.283
686.8365
686.3990
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
420.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C35H54N6O8/c1-19(2)17-24(38-32(45)28(36)20(3)4)33(46)40-15-7-9-26(40)30(43)37-25(18-22-11-13-23(42)14-12-22)34(47)41-16-8-10-27(41)31(44)39-29(21(5)6)35(48)49/h11-14,19-21,24-29,42H,7-10,15-18,36H2,1-6H3,(H,37,43)(H,38,45)(H,39,44)(H,48,49)/t24-,25-,26-,27-,28-,29-/m0/s1 InChIKey: SJWJRDJCZUZWHB-AQRCPPRCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
420.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C35H54N6O8/c1-19(2)17-24(38-32(45)28(36)20(3)4)33(46)40-15-7-9-26(40)30(43)37-25(18-22-11-13-23(42)14-12-22)34(47)41-16-8-10-27(41)31(44)39-29(21(5)6)35(48)49/h11-14,19-21,24-29,42H,7-10,15-18,36H2,1-6H3,(H,37,43)(H,38,45)(H,39,44)(H,48,49)/t24-,25-,26-,27-,28-,29-/m0/s1 InChIKey: SJWJRDJCZUZWHB-AQRCPPRCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6