Back to search

Peptide record

TPDB47131

ACE inhibitor from thornback ray muscle (Raja clavata) ACE inhibitors Antihypertensive Neuropeptide standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47131
ACE inhibitor from thornback ray muscle (Raja clavata)
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IVGRPR
Physicochemical Analysis
C30H56N12O7
ANDCEQHLKMFSTWY
R
696.85
12.40
2
0
2
+2
1.84
-0.383
113.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C30H56N12O7
696.85
12.40
+2
1.84
-0.383
696.8396
696.4383
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Lassoued I., Mora L., Barkia, Aristoy M.-C., Nasri M., Toldra F.
Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609, 2016
2016
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C30H56N12O7/c1-5-17(4)22(31)25(45)41-23(16(2)3)26(46)38-15-21(43)39-18(9-6-12-36-29(32)33)27(47)42-14-8-11-20(42)24(44)40-19(28(48)49)10-7-13-37-30(34)35/h16-20,22-23H,5-15,31H2,1-4H3,(H,38,46)(H,39,43)(H,40,44)(H,41,45)(H,48,49)(H4,32,33,36)(H4,34,35,37)/t17-,18-,19-,20-,22-,23-/m0/s1 InChIKey=AFTUKEFNJJDGPK-WAUHAFJUSA-N Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was >1000 uM.
Evidence 2 Activity

Activity

IC50
Antihypertensive
1000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Lassoued I., Mora L., Barkia, Aristoy M.-C., Nasri M., Toldra F.
Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609, 2016
2016
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C30H56N12O7/c1-5-17(4)22(31)25(45)41-23(16(2)3)26(46)38-15-21(43)39-18(9-6-12-36-29(32)33)27(47)42-14-8-11-20(42)24(44)40-19(28(48)49)10-7-13-37-30(34)35/h16-20,22-23H,5-15,31H2,1-4H3,(H,38,46)(H,39,43)(H,40,44)(H,41,45)(H,48,49)(H4,32,33,36)(H4,34,35,37)/t17-,18-,19-,20-,22-,23-/m0/s1 InChIKey=AFTUKEFNJJDGPK-WAUHAFJUSA-N Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was >1000 uM.
Additional Detail Fields 1 fields
6