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Peptide record

TPDB47129

ACE inhibitor (from bovine beta-CN) ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47129
ACE inhibitor (from bovine beta-CN)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LNVPGEIVE
Physicochemical Analysis
C43H72N10O15
ARDCQHKMFSTWY
EV
969.10
3.13
0
2
4
-2
4.19
0.467
151.11
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
2
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
9
C43H72N10O15
969.10
3.13
-2
4.19
0.467
969.0869
968.5161
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
300.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Gobbetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4. Appl. Environ. Microbiol., 66, 3898-3904, 2000
2000
dissertation

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C43H72N10O15/c1-9-23(8)35(41(65)50-33(21(4)5)40(64)48-26(43(67)68)13-15-32(58)59)52-37(61)25(12-14-31(56)57)47-30(55)19-46-39(63)28-11-10-16-53(28)42(66)34(22(6)7)51-38(62)27(18-29(45)54)49-36(60)24(44)17-20(2)3/h20-28,33-35H,9-19,44H2,1-8H3,(H2,45,54)(H,46,63)(H,47,55)(H,48,64)(H,49,60)(H,50,65)(H,51,62)(H,52,61)(H,56,57)(H,58,59)(H,67,68)/t23-,24-,25-,26-,27-,28-,33-,34-,35-/m0/s1 InChIKey=UYEBAICRFOUJMF-KFXKGJFASA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
300.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Gobbetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4. Appl. Environ. Microbiol., 66, 3898-3904, 2000
2000
dissertation

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C43H72N10O15/c1-9-23(8)35(41(65)50-33(21(4)5)40(64)48-26(43(67)68)13-15-32(58)59)52-37(61)25(12-14-31(56)57)47-30(55)19-46-39(63)28-11-10-16-53(28)42(66)34(22(6)7)51-38(62)27(18-29(45)54)49-36(60)24(44)17-20(2)3/h20-28,33-35H,9-19,44H2,1-8H3,(H2,45,54)(H,46,63)(H,47,55)(H,48,64)(H,49,60)(H,50,65)(H,51,62)(H,52,61)(H,56,57)(H,58,59)(H,67,68)/t23-,24-,25-,26-,27-,28-,33-,34-,35-/m0/s1 InChIKey=UYEBAICRFOUJMF-KFXKGJFASA-N
Additional Detail Fields 1 fields
9