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Peptide record

TPDB47126

ACE inhibitor from as2-casein ACE inhibitors Antihypertensive standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB47126
ACE inhibitor from as2-casein
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
ALNEINQFYQK
Physicochemical Analysis
C62H94N16O19
RDCGHMPSTWV
NQ
1367.52
6.87
1
1
5
-0
1.90
-0.891
80.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
108.96
5
Residue Composition
number
1
A
0
R
2
N
0
D
0
C
1
E
2
Q
0
G
0
H
1
I
1
L
1
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C62H94N16O19
1367.52
6.87
-0
1.90
-0.891
1367.5018
1366.6859
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
264.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tauzin J., Miclo L., Gaillard J. L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphas2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C62H94N16O19/c1-6-32(4)51(78-55(89)39(21-24-50(84)85)71-59(93)44(29-48(67)82)76-56(90)41(26-31(2)3)73-52(86)33(5)64)61(95)77-45(30-49(68)83)60(94)70-38(20-23-47(66)81)54(88)74-42(27-34-12-8-7-9-13-34)58(92)75-43(28-35-15-17-36(79)18-16-35)57(91)69-37(19-22-46(65)80)53(87)72-40(62(96)97)14-10-11-25-63/h7-9,12-13,15-18,31-33,37-45,51,79H,6,10-11,14,19-30,63-64H2,1-5H3,(H2,65,80)(H2,66,81)(H2,67,82)(H2,68,83)(H,69,91)(H,70,94)(H,71,93)(H,72,87)(H,73,86)(H,74,88)(H,75,92)(H,76,90)(H,77,95)(H,78,89)(H,84,85)(H,96,97)/t32-,33-,37-,38-,39-,40-,41-,42-,43-,44-,45-,51-/m0/s1 InChIKey=OBGALKJTIIOKLW-LHVJYZTOSA-N Produced by trypsin digestion. Predicted as antithrombotic peptide according to the BIOPEP-UWM Virtual database (ID 200) The DFBP database (ID DFBPANTH0141)
Evidence 2 Activity

Activity

IC50
Antihypertensive
264.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tauzin J., Miclo L., Gaillard J. L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphas2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C62H94N16O19/c1-6-32(4)51(78-55(89)39(21-24-50(84)85)71-59(93)44(29-48(67)82)76-56(90)41(26-31(2)3)73-52(86)33(5)64)61(95)77-45(30-49(68)83)60(94)70-38(20-23-47(66)81)54(88)74-42(27-34-12-8-7-9-13-34)58(92)75-43(28-35-15-17-36(79)18-16-35)57(91)69-37(19-22-46(65)80)53(87)72-40(62(96)97)14-10-11-25-63/h7-9,12-13,15-18,31-33,37-45,51,79H,6,10-11,14,19-30,63-64H2,1-5H3,(H2,65,80)(H2,66,81)(H2,67,82)(H2,68,83)(H,69,91)(H,70,94)(H,71,93)(H,72,87)(H,73,86)(H,74,88)(H,75,92)(H,76,90)(H,77,95)(H,78,89)(H,84,85)(H,96,97)/t32-,33-,37-,38-,39-,40-,41-,42-,43-,44-,45-,51-/m0/s1 InChIKey=OBGALKJTIIOKLW-LHVJYZTOSA-N Produced by trypsin digestion. Predicted as antithrombotic peptide according to the BIOPEP-UWM Virtual database (ID 200) The DFBP database (ID DFBPANTH0141)
Additional Detail Fields 1 fields
11