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Peptide record

TPDB47122

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47122
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PQNILP
Physicochemical Analysis
C31H52N8O9
ARDCEGHKMFSTWYV
P
680.80
6.02
0
0
2
-0
1.03
-0.317
130.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C31H52N8O9
680.80
6.02
-0
1.03
-0.317
680.7907
680.3845
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
440.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H52N8O9/c1-5-17(4)25(29(45)37-21(14-16(2)3)30(46)39-13-7-9-22(39)31(47)48)38-28(44)20(15-24(33)41)36-27(43)19(10-11-23(32)40)35-26(42)18-8-6-12-34-18/h16-22,25,34H,5-15H2,1-4H3,(H2,32,40)(H2,33,41)(H,35,42)(H,36,43)(H,37,45)(H,38,44)(H,47,48)/t17-,18-,19-,20-,21-,22-,25-/m0/s1 InChIKey: YPLKTZKZAVXJGJ-FGIKLMJHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
440.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H52N8O9/c1-5-17(4)25(29(45)37-21(14-16(2)3)30(46)39-13-7-9-22(39)31(47)48)38-28(44)20(15-24(33)41)36-27(43)19(10-11-23(32)40)35-26(42)18-8-6-12-34-18/h16-22,25,34H,5-15H2,1-4H3,(H2,32,40)(H2,33,41)(H,35,42)(H,36,43)(H,37,45)(H,38,44)(H,47,48)/t17-,18-,19-,20-,21-,22-,25-/m0/s1 InChIKey: YPLKTZKZAVXJGJ-FGIKLMJHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Additional Detail Fields 1 fields
6