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Peptide record

TPDB47119

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47119
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PVRAVP
Physicochemical Analysis
C29H51N9O7
NDCEQGHILKMFSTWY
PV
637.78
11.05
1
0
3
+1
1.68
0.417
113.33
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
6
C29H51N9O7
637.78
11.05
+1
1.68
0.417
637.7693
637.3900
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
170.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C29H51N9O7/c1-15(2)21(36-24(40)18-9-6-12-32-18)26(42)35-19(10-7-13-33-29(30)31)25(41)34-17(5)23(39)37-22(16(3)4)27(43)38-14-8-11-20(38)28(44)45/h15-22,32H,6-14H2,1-5H3,(H,34,41)(H,35,42)(H,36,40)(H,37,39)(H,44,45)(H4,30,31,33)/t17-,18-,19-,20-,21-,22-/m0/s1 InChIKey: QNHDFFKBMFJFAS-WLNPFYQQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
170.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C29H51N9O7/c1-15(2)21(36-24(40)18-9-6-12-32-18)26(42)35-19(10-7-13-33-29(30)31)25(41)34-17(5)23(39)37-22(16(3)4)27(43)38-14-8-11-20(38)28(44)45/h15-22,32H,6-14H2,1-5H3,(H,34,41)(H,35,42)(H,36,40)(H,37,39)(H,44,45)(H4,30,31,33)/t17-,18-,19-,20-,21-,22-/m0/s1 InChIKey: QNHDFFKBMFJFAS-WLNPFYQQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6