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Peptide record

TPDB47116

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47116
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PQTLALP
Physicochemical Analysis
C34H58N8O10
RNDCEGHIKMFSWYV
LP
738.88
6.02
0
0
3
-0
0.33
0.286
125.71
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
2
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C34H58N8O10
738.88
6.02
-0
0.33
0.286
738.8696
738.4262
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
110.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)[C@@H](C)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C34H58N8O10/c1-17(2)15-23(31(48)37-19(5)28(45)40-24(16-18(3)4)33(50)42-14-8-10-25(42)34(51)52)39-32(49)27(20(6)43)41-30(47)22(11-12-26(35)44)38-29(46)21-9-7-13-36-21/h17-25,27,36,43H,7-16H2,1-6H3,(H2,35,44)(H,37,48)(H,38,46)(H,39,49)(H,40,45)(H,41,47)(H,51,52)/t19-,20+,21-,22-,23-,24-,25-,27-/m0/s1 InChIKey: SYSRFESGFHHVEQ-HVJWLESQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
110.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)[C@@H](C)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C34H58N8O10/c1-17(2)15-23(31(48)37-19(5)28(45)40-24(16-18(3)4)33(50)42-14-8-10-25(42)34(51)52)39-32(49)27(20(6)43)41-30(47)22(11-12-26(35)44)38-29(46)21-9-7-13-36-21/h17-25,27,36,43H,7-16H2,1-6H3,(H2,35,44)(H,37,48)(H,38,46)(H,39,49)(H,40,45)(H,41,47)(H,51,52)/t19-,20+,21-,22-,23-,24-,25-,27-/m0/s1 InChIKey: SYSRFESGFHHVEQ-HVJWLESQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7