TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB47115

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

PPPVHL

FASTA

>TPDB47115|ACE inhibitors;Antihypertensive|length=6
PPPVHL

Formula C32H50N8O7

Absent Amino Acids ARNDCEQGIKMFSTWY

Common Amino Acids P

Mass 658.80

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +0

Boman Index 1.82

Hydrophobicity -0.000

Aliphatic Index 113.33

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

0

M

0

F

3

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

6

Formula

C32H50N8O7

Mass

658.80

PI

7.85

Net Charge

+0

Boman Index

1.82

Hydrophobicity

-0.000

Chemical_Mass

658.7868

Monoisotopic_Mass

658.3791

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Maruyama S., Miyoshi S., Kaneko T., Tanaka H.

Title

Angotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.Agric.Biol.Chem.53(4),1077-1081(1989)

Year 1989

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1)C(C)C)C(O)=O InChI=1S/C32H50N8O7/c1-18(2)14-23(32(46)47)37-27(41)22(15-20-16-33-17-35-20)36-29(43)26(19(3)4)38-28(42)24-9-6-12-39(24)31(45)25-10-7-13-40(25)30(44)21-8-5-11-34-21/h16-19,21-26,34H,5-15H2,1-4H3,(H,33,35)(H,36,43)(H,37,41)(H,38,42)(H,46,47)/t21-,22-,23-,24-,25-,26-/m0/s1 InChIKey=UABJQHMPBSXMCE-FRSCJGFNSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Maruyama S., Miyoshi S., Kaneko T., Tanaka H.

Title

Angotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.Agric.Biol.Chem.53(4),1077-1081(1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1)C(C)C)C(O)=O InChI=1S/C32H50N8O7/c1-18(2)14-23(32(46)47)37-27(41)22(15-20-16-33-17-35-20)36-29(43)26(19(3)4)38-28(42)24-9-6-12-39(24)31(45)25-10-7-13-40(25)30(44)21-8-5-11-34-21/h16-19,21-26,34H,5-15H2,1-4H3,(H,33,35)(H,36,43)(H,37,41)(H,38,42)(H,46,47)/t21-,22-,23-,24-,25-,26-/m0/s1 InChIKey=UABJQHMPBSXMCE-FRSCJGFNSA-N

Number_of_Residues

6