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Peptide record

TPDB47105

ACE inhibitor from alphas2-casein ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47105
ACE inhibitor from alphas2-casein
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
NMAINPSK
Physicochemical Analysis
C36H63N11O12S1
RDCEQGHLFTWYV
N
874.02
10.10
1
0
3
+1
1.70
-0.637
61.25
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
2
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
1
K
1
M
0
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 1 M: 1 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C36H63N11O12S1
874.02
10.10
+1
1.70
-0.637
874.0155
873.4364
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
60.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tauzin J., Miclo L., Gaillard J.-L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine αS2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C36H63N11O12S/c1-5-18(2)28(46-29(51)19(3)41-31(53)21(11-14-60-4)42-30(52)20(38)15-26(39)49)34(56)44-23(16-27(40)50)35(57)47-13-8-10-25(47)33(55)45-24(17-48)32(54)43-22(36(58)59)9-6-7-12-37/h18-25,28,48H,5-17,37-38H2,1-4H3,(H2,39,49)(H2,40,50)(H,41,53)(H,42,52)(H,43,54)(H,44,56)(H,45,55)(H,46,51)(H,58,59)/t18-,19-,20-,21-,22-,23-,24-,25-,28-/m0/s1 InChIKey=BEGCGHCUYHTCGZ-XUHYSJPJSA-N Produced by trypsin digestion. Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR) according to the BIOPEP-UWM Virtual database (ID 218) the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
60.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tauzin J., Miclo L., Gaillard J.-L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine αS2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C36H63N11O12S/c1-5-18(2)28(46-29(51)19(3)41-31(53)21(11-14-60-4)42-30(52)20(38)15-26(39)49)34(56)44-23(16-27(40)50)35(57)47-13-8-10-25(47)33(55)45-24(17-48)32(54)43-22(36(58)59)9-6-7-12-37/h18-25,28,48H,5-17,37-38H2,1-4H3,(H2,39,49)(H2,40,50)(H,41,53)(H,42,52)(H,43,54)(H,44,56)(H,45,55)(H,46,51)(H,58,59)/t18-,19-,20-,21-,22-,23-,24-,25-,28-/m0/s1 InChIKey=BEGCGHCUYHTCGZ-XUHYSJPJSA-N Produced by trypsin digestion. Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR) according to the BIOPEP-UWM Virtual database (ID 218) the DFBP database
Additional Detail Fields 1 fields
8