TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB47104

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

HQAAGW

FASTA

>TPDB47104|ACE inhibitors;Antihypertensive|length=6
HQAAGW

Formula C30H40N10O8

Absent Amino Acids RNDCEILKMFPSTYV

Common Amino Acids A

Mass 668.71

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index -0.64

Hydrophobicity -0.733

Aliphatic Index 33.33

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 822.48

Polar Residues 1

number

2

A

0

R

0

N

0

D

0

C

0

E

1

Q

1

G

1

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

6

Formula

C30H40N10O8

Mass

668.71

PI

7.85

Net Charge

+0

Boman Index

-0.64

Hydrophobicity

-0.733

Chemical_Mass

668.6992

Monoisotopic_Mass

668.3022

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 60.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kawamura Y., Sugimoto T., Takane S., Satake M.

Title Biryo Eiyoso Kenkyu, 6, 117-121

Year 1989

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O InChI=1S/C30H40N10O8/c1-15(26(43)35-13-25(42)39-23(30(47)48)9-17-11-34-21-6-4-3-5-19(17)21)37-27(44)16(2)38-29(46)22(7-8-24(32)41)40-28(45)20(31)10-18-12-33-14-36-18/h3-6,11-12,14-16,20,22-23,34H,7-10,13,31H2,1-2H3,(H2,32,41)(H,33,36)(H,35,43)(H,37,44)(H,38,46)(H,39,42)(H,40,45)(H,47,48)/t15-,16-,20-,22-,23-/m0/s1 InChIKey=NZTDPDKKUPECDS-PJCVJJCRSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 60.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kawamura Y., Sugimoto T., Takane S., Satake M.

Title Biryo Eiyoso Kenkyu, 6, 117-121

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O InChI=1S/C30H40N10O8/c1-15(26(43)35-13-25(42)39-23(30(47)48)9-17-11-34-21-6-4-3-5-19(17)21)37-27(44)16(2)38-29(46)22(7-8-24(32)41)40-28(45)20(31)10-18-12-33-14-36-18/h3-6,11-12,14-16,20,22-23,34H,7-10,13,31H2,1-2H3,(H2,32,41)(H,33,36)(H,35,43)(H,37,44)(H,38,46)(H,39,42)(H,40,45)(H,47,48)/t15-,16-,20-,22-,23-/m0/s1 InChIKey=NZTDPDKKUPECDS-PJCVJJCRSA-N

Number_of_Residues

6