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Peptide record

TPDB47103

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47103
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PAVVLP
Physicochemical Analysis
C29H50N6O7
RNDCEQGHIKMFSTWY
PV
594.75
6.02
0
0
4
-0
0.31
1.800
178.33
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
6
C29H50N6O7
594.75
6.02
-0
0.31
1.800
594.7413
594.3729
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
45.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53, 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of sensory peptides and amino acids SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C29H50N6O7/c1-15(2)14-20(28(40)35-13-9-11-21(35)29(41)42)32-26(38)22(16(3)4)34-27(39)23(17(5)6)33-24(36)18(7)31-25(37)19-10-8-12-30-19/h15-23,30H,8-14H2,1-7H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,41,42)/t18-,19-,20-,21-,22-,23-/m0/s1 InChIKey: SETABUIHFADUJK-LLINQDLYSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
45.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53, 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of sensory peptides and amino acids SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C29H50N6O7/c1-15(2)14-20(28(40)35-13-9-11-21(35)29(41)42)32-26(38)22(16(3)4)34-27(39)23(17(5)6)33-24(36)18(7)31-25(37)19-10-8-12-30-19/h15-23,30H,8-14H2,1-7H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,41,42)/t18-,19-,20-,21-,22-,23-/m0/s1 InChIKey: SETABUIHFADUJK-LLINQDLYSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Additional Detail Fields 1 fields
6