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Peptide record

TPDB47097

ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47097
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
GPAGAPGAA
Physicochemical Analysis
C28H45N9O10
RNDCEQHILKMFSTWYV
A
667.72
6.02
0
0
4
-0
0.25
0.311
44.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C28H45N9O10
667.72
6.02
-0
0.25
0.311
667.7094
667.3279
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Oshima H., Shimabukuro H., Nagasawa K.
Peptide inhibitors of angiotensin I-converting enzyme in digest of gelatin by bacterial collagenase. Biochim. Biophys. Acta, 566, 128-137
1979
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(C)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(C)NC(=O)CNC(=O)[C@]([H])(C)NC(=O)[C@]1([H])CCCN1C(=O)CN)C(O)=O InChI=1S/C28H45N9O10/c1-14(34-26(44)19-8-5-9-36(19)22(40)11-29)23(41)30-12-21(39)33-16(3)27(45)37-10-6-7-18(37)25(43)31-13-20(38)32-15(2)24(42)35-17(4)28(46)47/h14-19H,5-13,29H2,1-4H3,(H,30,41)(H,31,43)(H,32,38)(H,33,39)(H,34,44)(H,35,42)(H,46,47)/t14-,15-,16-,17-,18-,19-/m0/s1 InChIKey=BTJHVSJCGMWQSQ-DYKIIFRCSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Oshima H., Shimabukuro H., Nagasawa K.
Peptide inhibitors of angiotensin I-converting enzyme in digest of gelatin by bacterial collagenase. Biochim. Biophys. Acta, 566, 128-137
1979
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(C)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(C)NC(=O)CNC(=O)[C@]([H])(C)NC(=O)[C@]1([H])CCCN1C(=O)CN)C(O)=O InChI=1S/C28H45N9O10/c1-14(34-26(44)19-8-5-9-36(19)22(40)11-29)23(41)30-12-21(39)33-16(3)27(45)37-10-6-7-18(37)25(43)31-13-20(38)32-15(2)24(42)35-17(4)28(46)47/h14-19H,5-13,29H2,1-4H3,(H,30,41)(H,31,43)(H,32,38)(H,33,39)(H,34,44)(H,35,42)(H,46,47)/t14-,15-,16-,17-,18-,19-/m0/s1 InChIKey=BTJHVSJCGMWQSQ-DYKIIFRCSA-N
Additional Detail Fields 1 fields
9