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Peptide record

TPDB47094

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47094
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
RMLGQTPTK
Physicochemical Analysis
C43H78N14O13S1
ANDCEHIFSWYV
T
1031.24
11.49
2
0
2
+2
2.33
-1.067
43.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
1
L
1
K
1
M
0
F
1
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 1 M: 1 F: 0 P: 1 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C43H78N14O13S1
1031.24
11.49
+2
2.33
-1.067
1031.2284
1030.5576
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
34.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Katayama K., Tomatsu M., Fuchu H., Sugiyama M., Kawahara S., Muguruma M.
Purification and characterization of an angiotensin I-converting enzyme inhibitory peptide derived from porcine troponin C. Anim. Sci. J., 74, 53-58, 2003
2003
Journal

Other

9
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Evidence 2 Activity

Activity

IC50
Antihypertensive
34.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Katayama K., Tomatsu M., Fuchu H., Sugiyama M., Kawahara S., Muguruma M.
Purification and characterization of an angiotensin I-converting enzyme inhibitory peptide derived from porcine troponin C. Anim. Sci. J., 74, 53-58, 2003
2003
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Additional Detail Fields 1 fields
9