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Peptide record

TPDB47093

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47093
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PANIKWGD
Physicochemical Analysis
C41H61N11O12
RCEQHLMFSTYV
ANDGIKPW
900.00
6.75
1
1
3
-0
0.77
-0.938
61.25
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
611.11
1
Residue Composition
number
1
A
0
R
1
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C41H61N11O12
900.00
6.75
-0
0.77
-0.938
899.9871
899.4487
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
21.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohama Y., Oka H., Yamamoto K., Teramoto T., Okabe M., Mimura T., Nagase Y., Chiba Y., Fujita T.
Induction of angiotensin-converting enzyme inhibitory activity by acid-limited proteolysis of glyceraldehyde-3-phosphate dehydrogenase. Biochem. Biophys. Res. Commun., 161, 456-460
1989
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(O)=O)[C@@]([H])(C)CC InChI=1S/C41H61N11O12/c1-4-21(2)34(52-39(61)29(17-31(43)53)50-35(57)22(3)47-37(59)26-13-9-15-44-26)40(62)49-27(12-7-8-14-42)38(60)51-28(16-23-19-45-25-11-6-5-10-24(23)25)36(58)46-20-32(54)48-30(41(63)64)18-33(55)56/h5-6,10-11,19,21-22,26-30,34,44-45H,4,7-9,12-18,20,42H2,1-3H3,(H2,43,53)(H,46,58)(H,47,59)(H,48,54)(H,49,62)(H,50,57)(H,51,60)(H,52,61)(H,55,56)(H,63,64)/t21-,22-,26-,27-,28-,29-,30-,34-/m0/s1 InChIKey=HPIKMKCHEDDBFC-RVVDMIPZSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
21.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohama Y., Oka H., Yamamoto K., Teramoto T., Okabe M., Mimura T., Nagase Y., Chiba Y., Fujita T.
Induction of angiotensin-converting enzyme inhibitory activity by acid-limited proteolysis of glyceraldehyde-3-phosphate dehydrogenase. Biochem. Biophys. Res. Commun., 161, 456-460
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(O)=O)[C@@]([H])(C)CC InChI=1S/C41H61N11O12/c1-4-21(2)34(52-39(61)29(17-31(43)53)50-35(57)22(3)47-37(59)26-13-9-15-44-26)40(62)49-27(12-7-8-14-42)38(60)51-28(16-23-19-45-25-11-6-5-10-24(23)25)36(58)46-20-32(54)48-30(41(63)64)18-33(55)56/h5-6,10-11,19,21-22,26-30,34,44-45H,4,7-9,12-18,20,42H2,1-3H3,(H2,43,53)(H,46,58)(H,47,59)(H,48,54)(H,49,62)(H,50,57)(H,51,60)(H,52,61)(H,55,56)(H,63,64)/t21-,22-,26-,27-,28-,29-,30-,34-/m0/s1 InChIKey=HPIKMKCHEDDBFC-RVVDMIPZSA-N
Additional Detail Fields 1 fields
8