TPDB

3D PDB MODEL

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TPDB ID TPDB47091

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

KVLAGM

FASTA

>TPDB47091|ACE inhibitors;Antihypertensive|length=6
KVLAGM

Formula C27H51N7O7S1

Absent Amino Acids RNDCEQHIFPSTWY

Common Amino Acids AGLKMV

Mass 617.80

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index 0.11

Hydrophobicity 1.233

Aliphatic Index 130.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

1

K

1

M

0

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

6

Formula

C27H51N7O7S1

Mass

617.80

PI

10.10

Net Charge

+1

Boman Index

0.11

Hydrophobicity

1.233

Chemical_Mass

617.8006

Monoisotopic_Mass

617.3559

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 30.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Ukeda H., Matsuda H., Osajima K., Matsufuji H., Matsui T., and Osajima Y.

Title Nippon Nogeikagaku Kaishi 66, 25-29

Year 1992

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCSC)C(O)=O InChI=1S/C27H51N7O7S/c1-15(2)13-20(33-26(39)22(16(3)4)34-24(37)18(29)9-7-8-11-28)25(38)31-17(5)23(36)30-14-21(35)32-19(27(40)41)10-12-42-6/h15-20,22H,7-14,28-29H2,1-6H3,(H,30,36)(H,31,38)(H,32,35)(H,33,39)(H,34,37)(H,40,41)/t17-,18-,19-,20-,22-/m0/s1 InChIKey=WSRDIBQMQYKDQL-HVAMYJMISA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 30.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Ukeda H., Matsuda H., Osajima K., Matsufuji H., Matsui T., and Osajima Y.

Title Nippon Nogeikagaku Kaishi 66, 25-29

Year 1992

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCSC)C(O)=O InChI=1S/C27H51N7O7S/c1-15(2)13-20(33-26(39)22(16(3)4)34-24(37)18(29)9-7-8-11-28)25(38)31-17(5)23(36)30-14-21(35)32-19(27(40)41)10-12-42-6/h15-20,22H,7-14,28-29H2,1-6H3,(H,30,36)(H,31,38)(H,32,35)(H,33,39)(H,34,37)(H,40,41)/t17-,18-,19-,20-,22-/m0/s1 InChIKey=WSRDIBQMQYKDQL-HVAMYJMISA-N

Number_of_Residues

6