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Peptide record

TPDB47088

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47088
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
QVSLNSGYY
Physicochemical Analysis
C46H67N11O16
ARDCEHIKMFPTW
SY
1030.10
5.88
0
0
4
-0
-1.10
-0.400
75.56
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
2980
289.29
6
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
2
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
9
C46H67N11O16
1030.10
5.88
-0
-1.10
-0.400
1030.0856
1029.4751
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Gobetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks strated by Lactobacillus delbrueckii ssp. bulgaricus SS1 and Lactococcus lactis ssp. cremoris FT4. Appl. Environ. Microbiol., 66(9), 3898-3904
2000
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C46H67N11O16/c1-22(2)15-29(52-44(70)34(21-59)56-45(71)38(23(3)4)57-39(65)28(47)13-14-35(48)62)41(67)53-31(18-36(49)63)43(69)55-33(20-58)40(66)50-19-37(64)51-30(16-24-5-9-26(60)10-6-24)42(68)54-32(46(72)73)17-25-7-11-27(61)12-8-25/h5-12,22-23,28-34,38,58-61H,13-21,47H2,1-4H3,(H2,48,62)(H2,49,63)(H,50,66)(H,51,64)(H,52,70)(H,53,67)(H,54,68)(H,55,69)(H,56,71)(H,57,65)(H,72,73)/t28-,29-,30-,31-,32-,33-,34-,38-/m0/s1 InChIKey=IOPQJTAYLWZRMD-DWIHLTNRSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Gobetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks strated by Lactobacillus delbrueckii ssp. bulgaricus SS1 and Lactococcus lactis ssp. cremoris FT4. Appl. Environ. Microbiol., 66(9), 3898-3904
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C46H67N11O16/c1-22(2)15-29(52-44(70)34(21-59)56-45(71)38(23(3)4)57-39(65)28(47)13-14-35(48)62)41(67)53-31(18-36(49)63)43(69)55-33(20-58)40(66)50-19-37(64)51-30(16-24-5-9-26(60)10-6-24)42(68)54-32(46(72)73)17-25-7-11-27(61)12-8-25/h5-12,22-23,28-34,38,58-61H,13-21,47H2,1-4H3,(H2,48,62)(H2,49,63)(H,50,66)(H,51,64)(H,52,70)(H,53,67)(H,54,68)(H,55,69)(H,56,71)(H,57,65)(H,72,73)/t28-,29-,30-,31-,32-,33-,34-,38-/m0/s1 InChIKey=IOPQJTAYLWZRMD-DWIHLTNRSA-N
Additional Detail Fields 1 fields
9