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Peptide record

TPDB47084

ACE inhibitors derived from yeast GADPH ACE inhibitors Antihypertensive standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB47084
ACE inhibitors derived from yeast GADPH
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PANLPWGSSNV
Physicochemical Analysis
C51H76N14O16
RDCEQHIKMFTY
NPS
1141.25
6.02
0
0
4
-0
-0.50
-0.300
70.91
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
481.93
4
Residue Composition
number
1
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
11
C51H76N14O16
1141.25
6.02
-0
-0.50
-0.300
1141.2303
1140.5546
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
18.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohama Y., Nagase Y., Oka H., Nakagawa T., Teramoto T., Murayama N., Tsujibo H.,
Production of angiotensin-converting enzyme inhibitors from baker's yeasts Glyceraldehyde-3-phosphate Dehydrogenase. J. Pharmacobio-Dyn. 13, 766-771
1990
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(O)=O InChI=1S/C51H76N14O16/c1-24(2)16-34(62-45(74)32(18-38(52)68)59-42(71)26(5)57-44(73)30-12-8-14-54-30)50(79)65-15-9-13-37(65)49(78)61-31(17-27-20-55-29-11-7-6-10-28(27)29)43(72)56-21-40(70)58-35(22-66)47(76)63-36(23-67)48(77)60-33(19-39(53)69)46(75)64-41(25(3)4)51(80)81/h6-7,10-11,20,24-26,30-37,41,54-55,66-67H,8-9,12-19,21-23H2,1-5H3,(H2,52,68)(H2,53,69)(H,56,72)(H,57,73)(H,58,70)(H,59,71)(H,60,77)(H,61,78)(H,62,74)(H,63,76)(H,64,75)(H,80,81)/t26-,30-,31-,32-,33-,34-,35-,36-,37-,41-/m0/s1 InChIKey=KGDYXGWOWUNPTR-LUTHQIGCSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
18.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohama Y., Nagase Y., Oka H., Nakagawa T., Teramoto T., Murayama N., Tsujibo H.,
Production of angiotensin-converting enzyme inhibitors from baker's yeasts Glyceraldehyde-3-phosphate Dehydrogenase. J. Pharmacobio-Dyn. 13, 766-771
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(O)=O InChI=1S/C51H76N14O16/c1-24(2)16-34(62-45(74)32(18-38(52)68)59-42(71)26(5)57-44(73)30-12-8-14-54-30)50(79)65-15-9-13-37(65)49(78)61-31(17-27-20-55-29-11-7-6-10-28(27)29)43(72)56-21-40(70)58-35(22-66)47(76)63-36(23-67)48(77)60-33(19-39(53)69)46(75)64-41(25(3)4)51(80)81/h6-7,10-11,20,24-26,30-37,41,54-55,66-67H,8-9,12-19,21-23H2,1-5H3,(H2,52,68)(H2,53,69)(H,56,72)(H,57,73)(H,58,70)(H,59,71)(H,60,77)(H,61,78)(H,62,74)(H,63,76)(H,64,75)(H,80,81)/t26-,30-,31-,32-,33-,34-,35-,36-,37-,41-/m0/s1 InChIKey=KGDYXGWOWUNPTR-LUTHQIGCSA-N
Additional Detail Fields 1 fields
11