TPDB

3D PDB MODEL

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TPDB ID TPDB47079

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

AVNPIR

FASTA

>TPDB47079|ACE inhibitors;Antihypertensive|length=6
AVNPIR

Formula C29H52N10O8

Absent Amino Acids DCEQGHLKMFSTWY

Common Amino Acids ARNIPV

Mass 668.79

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 1.27

Hydrophobicity 0.150

Aliphatic Index 130.00

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

1

R

1

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

6

Formula

C29H52N10O8

Mass

668.79

PI

11.05

Net Charge

+1

Boman Index

1.27

Hydrophobicity

0.150

Chemical_Mass

668.7833

Monoisotopic_Mass

668.3958

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 13.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Maruyama S., Miyoshi S., Tanaka H.

Title Angiotensin I-converting enzyme inhibitors derived from ficus carica.Agric.Biol.Chem.53(10),2763-2767(1989)

Year 1989

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O)[C@@]([H])(C)CC InChI=1S/C29H52N10O8/c1-6-15(4)22(26(44)35-17(28(46)47)9-7-11-34-29(32)33)38-24(42)19-10-8-12-39(19)27(45)18(13-20(31)40)36-25(43)21(14(2)3)37-23(41)16(5)30/h14-19,21-22H,6-13,30H2,1-5H3,(H2,31,40)(H,35,44)(H,36,43)(H,37,41)(H,38,42)(H,46,47)(H4,32,33,34)/t15-,16-,17-,18-,19-,21-,22-/m0/s1 InChIKey=AOFPFGSHTSONOG-UMWWKMARSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 13.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Maruyama S., Miyoshi S., Tanaka H.

Title Angiotensin I-converting enzyme inhibitors derived from ficus carica.Agric.Biol.Chem.53(10),2763-2767(1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O)[C@@]([H])(C)CC InChI=1S/C29H52N10O8/c1-6-15(4)22(26(44)35-17(28(46)47)9-7-11-34-29(32)33)38-24(42)19-10-8-12-39(19)27(45)18(13-20(31)40)36-25(43)21(14(2)3)37-23(41)16(5)30/h14-19,21-22H,6-13,30H2,1-5H3,(H2,31,40)(H,35,44)(H,36,43)(H,37,41)(H,38,42)(H,46,47)(H4,32,33,34)/t15-,16-,17-,18-,19-,21-,22-/m0/s1 InChIKey=AOFPFGSHTSONOG-UMWWKMARSA-N

Number_of_Residues

6