TPDB

3D PDB MODEL

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TPDB ID TPDB47077

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

LKVGVKQY

FASTA

>TPDB47077|ACE inhibitors;Antihypertensive|length=8
LKVGVKQY

Formula C44H75N11O11

Absent Amino Acids ARNDCEHIMFPSTW

Common Amino Acids KV

Mass 934.15

PI 10.20

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +2

Boman Index 1.21

Hydrophobicity -0.100

Aliphatic Index 121.25

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 159.50

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

1

G

0

H

0

I

1

L

2

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2

Length

8

Formula

C44H75N11O11

Mass

934.15

PI

10.20

Net Charge

+2

Boman Index

1.21

Hydrophobicity

-0.100

Chemical_Mass

934.1304

Monoisotopic_Mass

933.5630

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 11.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Suetsuna K., Morigushi S., Kishino Y.

Title Abstract Papers of the 44th Nippon Eiyo Shokuryo Gakkai, p 223

Year 1990

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C44H75N11O11/c1-24(2)21-29(47)38(59)50-31(12-8-10-20-46)41(62)55-36(25(3)4)42(63)49-23-35(58)54-37(26(5)6)43(64)52-30(11-7-9-19-45)39(60)51-32(17-18-34(48)57)40(61)53-33(44(65)66)22-27-13-15-28(56)16-14-27/h13-16,24-26,29-33,36-37,56H,7-12,17-23,45-47H2,1-6H3,(H2,48,57)(H,49,63)(H,50,59)(H,51,60)(H,52,64)(H,53,61)(H,54,58)(H,55,62)(H,65,66)/t29-,30-,31-,32-,33-,36-,37-/m0/s1 InChIKey=VKEIQNSYYBGSJW-XBNMCGGNSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 11.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Suetsuna K., Morigushi S., Kishino Y.

Title Abstract Papers of the 44th Nippon Eiyo Shokuryo Gakkai, p 223

Year 1990

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C44H75N11O11/c1-24(2)21-29(47)38(59)50-31(12-8-10-20-46)41(62)55-36(25(3)4)42(63)49-23-35(58)54-37(26(5)6)43(64)52-30(11-7-9-19-45)39(60)51-32(17-18-34(48)57)40(61)53-33(44(65)66)22-27-13-15-28(56)16-14-27/h13-16,24-26,29-33,36-37,56H,7-12,17-23,45-47H2,1-6H3,(H2,48,57)(H,49,63)(H,50,59)(H,51,60)(H,52,64)(H,53,61)(H,54,58)(H,55,62)(H,65,66)/t29-,30-,31-,32-,33-,36-,37-/m0/s1 InChIKey=VKEIQNSYYBGSJW-XBNMCGGNSA-N

Number_of_Residues

8