TPDB

3D PDB MODEL

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TPDB ID TPDB47072

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

FQKVVAG

FASTA

>TPDB47072|ACE inhibitors;Antihypertensive|length=7
FQKVVAG

Formula C35H57N9O9

Absent Amino Acids RNDCEHILMPSTWY

Common Amino Acids V

Mass 747.89

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index 0.42

Hydrophobicity 0.743

Aliphatic Index 97.14

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

1

Q

1

G

0

H

0

I

0

L

1

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

7

Formula

C35H57N9O9

Mass

747.89

PI

10.10

Net Charge

+1

Boman Index

0.42

Hydrophobicity

0.743

Chemical_Mass

747.8797

Monoisotopic_Mass

747.4266

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 7.40 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.

Title

Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98

Year 1996

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(O)=O InChI=1S/C35H57N9O9/c1-19(2)28(34(52)40-21(5)30(48)39-18-27(46)47)44-35(53)29(20(3)4)43-33(51)24(13-9-10-16-36)42-32(50)25(14-15-26(38)45)41-31(49)23(37)17-22-11-7-6-8-12-22/h6-8,11-12,19-21,23-25,28-29H,9-10,13-18,36-37H2,1-5H3,(H2,38,45)(H,39,48)(H,40,52)(H,41,49)(H,42,50)(H,43,51)(H,44,53)(H,46,47)/t21-,23-,24-,25-,28-,29-/m0/s1 InChIKey=NMFAOOJBXGPRHL-YQMKVEMISA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 7.40 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.

Title

Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(O)=O InChI=1S/C35H57N9O9/c1-19(2)28(34(52)40-21(5)30(48)39-18-27(46)47)44-35(53)29(20(3)4)43-33(51)24(13-9-10-16-36)42-32(50)25(14-15-26(38)45)41-31(49)23(37)17-22-11-7-6-8-12-22/h6-8,11-12,19-21,23-25,28-29H,9-10,13-18,36-37H2,1-5H3,(H2,38,45)(H,39,48)(H,40,52)(H,41,49)(H,42,50)(H,43,51)(H,44,53)(H,46,47)/t21-,23-,24-,25-,28-,29-/m0/s1 InChIKey=NMFAOOJBXGPRHL-YQMKVEMISA-N

Number_of_Residues

7