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Peptide record

TPDB47071

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB47071
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
SAYPGQITSN
Physicochemical Analysis
C44H68N12O17
RDCEHLKMFWV
S
1037.09
5.94
0
0
3
-0
0.44
-0.630
49.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
143.67
6
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
2
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C44H68N12O17
1037.09
5.94
-0
0.44
-0.630
1037.0782
1036.4809
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Gobetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks strated by Lactobacillus delbrueckii ssp. bulgaricus SS1 and Lactococcus lactis ssp. cremoris FT4. Appl. Environ. Microbiol., 66(9), 3898-3904.
2000
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(N)CO)[C@@]([H])(C)CC)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(N)=O)C(O)=O InChI=1S/C44H68N12O17/c1-5-20(2)34(41(69)55-35(22(4)59)42(70)53-29(19-58)39(67)52-28(44(72)73)16-32(47)62)54-38(66)26(12-13-31(46)61)50-33(63)17-48-40(68)30-7-6-14-56(30)43(71)27(15-23-8-10-24(60)11-9-23)51-36(64)21(3)49-37(65)25(45)18-57/h8-11,20-22,25-30,34-35,57-60H,5-7,12-19,45H2,1-4H3,(H2,46,61)(H2,47,62)(H,48,68)(H,49,65)(H,50,63)(H,51,64)(H,52,67)(H,53,70)(H,54,66)(H,55,69)(H,72,73)/t20-,21-,22+,25-,26-,27-,28-,29-,30-,34-,35-/m0/s1 InChIKey=WOWGNGJPLMRKEH-QONYWWETSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Gobetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks strated by Lactobacillus delbrueckii ssp. bulgaricus SS1 and Lactococcus lactis ssp. cremoris FT4. Appl. Environ. Microbiol., 66(9), 3898-3904.
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(N)CO)[C@@]([H])(C)CC)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(N)=O)C(O)=O InChI=1S/C44H68N12O17/c1-5-20(2)34(41(69)55-35(22(4)59)42(70)53-29(19-58)39(67)52-28(44(72)73)16-32(47)62)54-38(66)26(12-13-31(46)61)50-33(63)17-48-40(68)30-7-6-14-56(30)43(71)27(15-23-8-10-24(60)11-9-23)51-36(64)21(3)49-37(65)25(45)18-57/h8-11,20-22,25-30,34-35,57-60H,5-7,12-19,45H2,1-4H3,(H2,46,61)(H2,47,62)(H,48,68)(H,49,65)(H,50,63)(H,51,64)(H,52,67)(H,53,70)(H,54,66)(H,55,69)(H,72,73)/t20-,21-,22+,25-,26-,27-,28-,29-,30-,34-,35-/m0/s1 InChIKey=WOWGNGJPLMRKEH-QONYWWETSA-N
Additional Detail Fields 1 fields
10