TPDB

3D PDB MODEL

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TPDB ID TPDB47066

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive Umami

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin Tastepeptides-Meta

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Umami) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

FQKVVA

FASTA

>TPDB47066|ACE inhibitors;Antihypertensive;Umami|length=6
FQKVVA

Formula C33H54N8O8

Absent Amino Acids RNDCEGHILMPSTWY

Common Amino Acids V

Mass 690.84

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index 0.41

Hydrophobicity 0.933

Aliphatic Index 113.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

1

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

6

Formula

C33H54N8O8

Mass

690.84

PI

10.10

Net Charge

+1

Boman Index

0.41

Hydrophobicity

0.933

Chemical_Mass

690.8285

Monoisotopic_Mass

690.4052

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 5.80 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.

Title

Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98

Year 1996

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C33H54N8O8/c1-18(2)26(31(46)37-20(5)33(48)49)41-32(47)27(19(3)4)40-30(45)23(13-9-10-16-34)39-29(44)24(14-15-25(36)42)38-28(43)22(35)17-21-11-7-6-8-12-21/h6-8,11-12,18-20,22-24,26-27H,9-10,13-17,34-35H2,1-5H3,(H2,36,42)(H,37,46)(H,38,43)(H,39,44)(H,40,45)(H,41,47)(H,48,49)/t20-,22-,23-,24-,26-,27-/m0/s1 InChIKey=CVODAHKQJLUBJH-PQJTZWKESA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 5.80 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.

Title

Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C33H54N8O8/c1-18(2)26(31(46)37-20(5)33(48)49)41-32(47)27(19(3)4)40-30(45)23(13-9-10-16-34)39-29(44)24(14-15-25(36)42)38-28(43)22(35)17-21-11-7-6-8-12-21/h6-8,11-12,18-20,22-24,26-27H,9-10,13-17,34-35H2,1-5H3,(H2,36,42)(H,37,46)(H,38,43)(H,39,44)(H,40,45)(H,41,47)(H,48,49)/t20-,22-,23-,24-,26-,27-/m0/s1 InChIKey=CVODAHKQJLUBJH-PQJTZWKESA-N

Number_of_Residues

6