TPDB

3D PDB MODEL

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TPDB ID TPDB47059

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

FQKVVAK

FASTA

>TPDB47059|ACE inhibitors;Antihypertensive|length=7
FQKVVAK

Formula C39H66N10O9

Absent Amino Acids RNDCEGHILMPSTWY

Common Amino Acids KV

Mass 819.01

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +2

Boman Index 1.40

Hydrophobicity 0.243

Aliphatic Index 97.14

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

2

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

7

Formula

C39H66N10O9

Mass

819.01

PI

10.60

Net Charge

+2

Boman Index

1.40

Hydrophobicity

0.243

Chemical_Mass

819.0003

Monoisotopic_Mass

818.4999

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 2.10 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.

Title

Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98

Year 1996

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C39H66N10O9/c1-22(2)31(37(55)44-24(5)33(51)47-29(39(57)58)16-10-12-20-41)49-38(56)32(23(3)4)48-36(54)27(15-9-11-19-40)46-35(53)28(17-18-30(43)50)45-34(52)26(42)21-25-13-7-6-8-14-25/h6-8,13-14,22-24,26-29,31-32H,9-12,15-21,40-42H2,1-5H3,(H2,43,50)(H,44,55)(H,45,52)(H,46,53)(H,47,51)(H,48,54)(H,49,56)(H,57,58)/t24-,26-,27-,28-,29-,31-,32-/m0/s1 InChIKey=CYSVCIFMXXCALD-YUQDWORRSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 2.10 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.

Title

Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C39H66N10O9/c1-22(2)31(37(55)44-24(5)33(51)47-29(39(57)58)16-10-12-20-41)49-38(56)32(23(3)4)48-36(54)27(15-9-11-19-40)46-35(53)28(17-18-30(43)50)45-34(52)26(42)21-25-13-7-6-8-14-25/h6-8,13-14,22-24,26-29,31-32H,9-12,15-21,40-42H2,1-5H3,(H2,43,50)(H,44,55)(H,45,52)(H,46,53)(H,47,51)(H,48,54)(H,49,56)(H,57,58)/t24-,26-,27-,28-,29-,31-,32-/m0/s1 InChIKey=CYSVCIFMXXCALD-YUQDWORRSA-N

Number_of_Residues

7